Search

Triple negative breast cancer (TNBC) is highly immunogenic and high levels of tumor infiltrating lymphocytes (TILs) have been associated with a better prognosis and higher probability to achieve pathological complete response. Here, we explore the potential role of stromal TILs level and composition as a prognostic and predictive biomarker in TNBC. 195 Tumor biospecimens from patients diagnosed with TNBC were included. Stromal TILs (sTILs), positive CD4/CD8 cells were evaluated. Differences in clinic-pathological characteristics according to immune infiltration were assessed. The predictive and prognostic value of immune infiltration was analyzed by multivariate models. Higher immune infiltration was observed in patients with favorable clinical-pathological features. Survival analysis showed that longer overall survival times were observed in patients with a higher infiltration of sTILs (p = 0.00043), CD4 + (p = 0.0074) and CD8 + (p = 0.008). In the multivariate analysis, low levels of sTILs were found to be associated with a higher mortality hazard (HR: 1.59, 95% CI 1.01-2.48). CD4 and CD8 immune infiltration were associated with higher odds for pathological complete response (OR: 1.20, 95% CI 1.00-1.46, OR: 1.28, 1.02-1.65, respectively). Our results suggest that immune infiltration could be used as a prognostic marker for overall survival in TNBC patients.

Handleyomys intectus (Thomas, 1921) is a rodent commonly called the Colombian rice rat or white-footed Handley's mouse. It is a dull brownish-gray to blackish small mouse with frosted ventral pelage and with dark gray and pure-white (or indistinctly pigmented) hairs over the dorsum of hindfeet. H. intectus is endemic to the Central Andes of Colombia and it is known from several localities between 1,500 and 2,800 m. It may be a common species along its distribution. Globally, it is considered "Least Concern" by the International Union for Conservation of Nature and Natural Resources. [ABSTRACT FROM AUTHOR]