1. Fabrication of a PLGA-collagen peripheral nerve scaffold and investigation of its sustained release property in vitro.
- Author
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Liu B, Cai SX, Ma KW, Xu ZL, Dai XZ, Yang L, Lin C, Fu XB, Sung KL, and Li XK
- Subjects
- Animals, Behavior, Animal drug effects, Cell Adhesion drug effects, Cell-Free System drug effects, Cell-Free System ultrastructure, Cells, Cultured, Delayed-Action Preparations administration & dosage, Delayed-Action Preparations pharmacokinetics, Extracellular Matrix chemistry, Extracellular Matrix ultrastructure, Female, Male, Microspheres, Nerve Regeneration drug effects, Nerve Regeneration physiology, Polylactic Acid-Polyglycolic Acid Copolymer, Rabbits, Serum Albumin, Bovine administration & dosage, Serum Albumin, Bovine pharmacokinetics, Collagen chemistry, Drug Carriers chemical synthesis, Drug Carriers pharmacokinetics, Lactic Acid chemistry, Peripheral Nerves drug effects, Peripheral Nerves physiology, Polyglycolic Acid chemistry, Tissue Scaffolds chemistry
- Abstract
This study deals with the fabrication of a peripheral nerve scaffold prepared with poly (lactic acid-co-glycolic acid) [PLGA] and acellularized pigskin collagen micro particles and the investigation of its sustained release property in vitro. We took bovine serum albumin [BSA] as model drug to investigate the sustained-release property of the scaffold in vitro. The results showed the scaffold could release BSA steadily with a rate of 6.6 ng/d (r=0.994) or so. In a 1-month test period, the accumulative release ratio of BSA from the scaffold was up to 43%, and the shape of the scaffold was still originally well kept. In addition, the scaffold outcome non-immunogenicity, good cell adhesion and biodegradability. The results indicated a scaffold constructed by this technique would be a potential implanting support with prolonged sustained release function, such as for the use of nerve scaffold.
- Published
- 2008
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