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Interestingly, 2 reported patients with colitis were found to have focal neutrophil infiltrates while follow-up mechanistic studies showed that DOCK2-defective neutrophils have impaired F-actin polymerization, motility, and respiratory burst [[3]]. To demonstrate that the patient's mutation does not result in stable DOCK2 protein expression, proteins were extracted from the patient's primary fibroblast culture and analyzed by immunoblotting as described in [[4]]. Keywords: DOCK2; primary immunodeficiency; Hematopoietic stem cell transplantation; combined immunodeficiency; Colitis EN DOCK2 primary immunodeficiency Hematopoietic stem cell transplantation combined immunodeficiency Colitis 1400 1402 3 07/27/21 20210801 NES 210801 Katherine D'Astous-Gauthier and Aléhandra Desjardins contributed equally to this manuscript. [Extracted from the article]