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The Eriksen Flanker task is a classic paradigm for investigating interference at the level of response compatibility. Several previous studies analyzed the ability of young children (starting at the age of four years) to ignore flanking distractors in children-specific variants of the task. However, in all published studies the interference took place at the perceptual level as well as on the level of response compatibility because the ‘compatible condition’ involved stimulus congruency as well as response compatibility. By confounding stimulus congruency and response compatibility, interference at the level of response programming and priming at the perceptual level cannot be distinguished: the observed flanker effects might not be the result of successfully ignoring but instead might just be explained due to priming. We tested 57 children aged between 7 and 12 years in a flanker variant in which all trials were perceptually incongruent but different at the level of response compatibility (compatible versus incompatible). Children showed a flanker effect (faster reaction times in response compatible trials) that was, however, in terms of the effect size, smaller than flanker effects reported in previous studies. [ABSTRACT FROM PUBLISHER]

• No evidence for isolated, but impairment in the interaction, of magno (M)- and parvocellular (P) pathways in schizophrenia. • Heightened association between visual processing and cognitive performance in schizophrenia. • N80 Latency as a potential biomarker for cognitive deficits in schizophrenia. Cognitive deficits and visual impairment in the magnocellular (M) pathway, have been independently reported in schizophrenia. The current study examined the association between neuropsychological (NPS) performance and visual evoked potentials (VEPs: N80/P1 to M- and P(parvocellular)-biased visual stimuli) in schizophrenia and healthy controls. NPS performance and VEPs were measured in n = 44 patients and n = 34 matched controls. Standardized NPS-scores were combined into Domains and a PCA (Principal Component Analysis) generated Composite. Group differences were assessed via (M)ANOVAs, association between NPS and VEP parameters via PCA, Pearson's coefficient and bootstrapping. Logistic regression was employed to assess classification power. Patients showed general cognitive impairment, whereas group differences for VEP-parameters were non-significant. In patients, N80 latency across conditions loaded onto one factor with cognitive composite, showed significant negative correlations of medium effect sizes with NPS performance for M/P mixed stimuli and classified low and high performance with 70% accuracy. The study provides no evidence for early visual pathway impairment but suggests a heightened association between early visual processing and cognitive performance in schizophrenia. Our results lend support to bottom-up models of cognitive function in schizophrenia and implicate visual N80 latency as a potential biomarker of cognitive deficits in schizophrenia. [ABSTRACT FROM AUTHOR]

Objectives: Patients with schizophrenia commonly suffer from impairments in various aspects of cognition. These deficits were shown to have detrimental effects on daily life functioning and might also impair car driving. This study is the first to examine driving behaviour of patients with schizophrenia using an advanced driving simulator, and to explore the role of cognitive abilities of people with schizophrenia for driving.Methods: Non-acute patients with schizophrenia (n = 31) and healthy comparison participants (n = 31) performed a comprehensive neuropsychological assessment and driving simulator rides. Neuropsychological and driving performances were compared between groups. Moreover, associations were explored between cognitive functions and driving behaviour in the entire group.Results: Patients with schizophrenia revealed impairments in multiple aspects of cognition. In the driving simulator, patients with schizophrenia showed no indication of deviant driving in terms of number of collisions or reacting to critical situations, and even showed better lane control compared to healthy individuals. However, patients with schizophrenia drove significantly slower than healthy individuals, and caused more hindrance to the car behind while merging on the motorway. Slower driving was associated with lower test scores on attention and processing speed. Hindering the car behind was associated with test performance on planning and inhibition.Conclusions: It is concluded that driving of patients with schizophrenia is characterized by a relatively slow speed, and can also be impaired in certain aspects, i.e. hindering a car behind while merging. Cognitive functions are crucial for driving, and should be target of treatment. [ABSTRACT FROM AUTHOR]