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3 results on '"Yeshiva University, NY"'

1. Preliminary Findings of the Brief Everyday Activities Measurement (BEAM) in Older Adults.

Author

Scharaga EA and Holtzer R

Subjects
Aged, Aged, 80 and over, Female, Humans, Male, Mass Screening methods, Reproducibility of Results, Activities of Daily Living psychology, Attention, Cognition, Cognition Disorders diagnosis, Executive Function, Financial Management, Self Administration
Abstract

Objectives: Functional losses are common in healthy and cognitively impaired older adults. However, subtle declines in instrumental activities of daily living (IADLs) are not always detected in self-reports. Performance IADL measurements are financially and time burdensome, restricting their use in varied settings. To address these limitations, we developed the Brief Everyday Activities Measure (BEAM), a short (< 5 minutes) objective IADL measure that assesses medication and finance management., Design and Participants: The BEAM was administered to 209 cognitively non-demented community-dwellers (ages 65 - 95 years)., Measurements: Participants completed standardized motor, neuropsychological, psychological, and self-report functional assessments., Results: BEAM completion time ranged from 54.16 to 259.31 seconds. Interclass correlations (ICC) for total BEAM completion time was moderate (0.65, 95% CI [.43 -.78]). Accuracy for total BEAM performance was in the low-moderate range (Kappa = 0.38, p < .001, 95% CI [.18 -.54]). As predicted, lower accuracy and longer time to complete the BEAM were both associated with worse executive functions, attention, and processing speed., Conclusions: Medication and finance management can be efficiently assessed within five minutes. The BEAM may be a valuable screening tool to evaluate these functional abilities.

Published
2015
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2. The relationship between specific cognitive functions and falls in aging.

Author

Holtzer R, Friedman R, Lipton RB, Katz M, Xue X, and Verghese J

Subjects
Aged, Aged, 80 and over, Female, Gait Disorders, Neurologic physiopathology, Humans, Logistic Models, Male, Neuropsychological Tests, Principal Component Analysis, Retrospective Studies, Severity of Illness Index, Accidental Falls, Aging, Cognition physiology, Geriatric Assessment
Abstract

The current study examined the relationship between cognitive function and falls in older people who did not meet criteria for dementia or mild cognitive impairment (N = 172). To address limitations of previous research, the authors controlled for the confounding effects of gait measures and other risk factors by means of associations between cognitive function and falls. A neuropsychological test battery was submitted to factor analysis, yielding 3 orthogonal factors (Verbal IQ, Speed/Executive Attention, Memory). Single and recurrent falls within the last 12 months were evaluated. The authors hypothesized that Speed/Executive Attention would be associated with falls. Additionally, the authors assessed whether associations between different cognitive functions and falls varied depending on whether single or recurrent falls were examined. Multivariate logistic regressions showed that lower scores on Speed/Executive Attention were associated with increased risk of single and recurrent falls. Lower scores on Verbal IQ were related only to increased risk of recurrent falls. Memory was not associated with either single or recurrent falls. These findings are relevant to risk assessment and prevention of falls and point to possible shared neural substrates of cognitive and motor function., ((PsycINFO Database Record (c) 2007 APA, all rights reserved).)

Published
2007
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3. APOE ε4 and the influence of sex, age, vascular risk factors, and ethnicity on cognitive decline

Author

Allison E. Aiello, Mary Ganguli, Sophie Carles, Jessica W. Lo, Jorge J. Llibre-Guerra, Ma Shwe Zin Nyunt, Linda Lam, Blossom C. M. Stephan, Mindy J. Katz, Wai Chi Chan, Ki Woong Kim, Yvonne Leung, Steve R. Makkar, Kaarin J. Anstey, CuilingWang, Seung Wan Suh, John D. Crawford, Mary N. Haan, Fiona E. Matthews, Adolfo J. Valhuerdi-Cepero, Henry Brodaty, Qi Gao, Alexander Pabst, Breno S. Diniz, Susanne Roehr, Steffi G. Riedel-Heller, Karen Ritchie, Mary Yannakoulia, Ada Fung, Mary H. Kosmidis, Ji Won Han, Julian N. Trollor, Simon Easteal, Annalisa Davin, Tze Pin Ng, Beth E. Snitz, Roberta Vaccaro, Darren M. Lipnicki, Juan J. Llibre-Rodriguez, Maria Fernanda Lima-Costa, Perminder S. Sachdev, Nikolaos Scarmeas, Richard B. Lipton, Nicole A. Kochan, Erico Castro-Costa, Tiffany F. Hughes, Nicolas Cherbuin, Carol Brayne, Isabelle Carrière, Kristina Dang, Antonio Guaita, University of New South Wales [Sydney] (UNSW), Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), University of Toronto, Center For Addiction and Mental Health, University of Cambridge [UK] (CAM), Newcastle University [Newcastle], University of Havana (Universidad de la Habana) (UH), University of California [San Francisco] (UCSF), University of California, Universidad de Matanzas, Yeshiva University, NY, Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital de la Colombière, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Paris Descartes - Paris 5 (UPD5), National and Kapodistrian University of Athens (NKUA), Columbia University [New York], Harokopio University of Athens, Aristotle University of Thessaloniki, The Chinese University of Hong Kong [Hong Kong], The Hong Kong Polytechnic University [Hong Kong] (POLYU), Golgi Cenci Foundation, Seoul National University [Seoul] (SNU), Seoul National University Hospital, Universität Leipzig [Leipzig], University of Pittsburgh School of Medicine, Pennsylvania Commonwealth System of Higher Education (PCSHE), Youngstown State University (YSU), Neuroscience Research Australia (NeuRA), Australian National University (ANU), University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), National University of Singapore (NUS), University of Nottingham Malaysia Campus, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), and Le Couteur, David

Subjects
Apolipoprotein E, Male, Aging, APOE genotype, Epidemiology, [SDV]Life Sciences [q-bio], Apolipoprotein E4, Ethnic group, Cognitive decline, Vascular risk, Neurodegenerative, Alzheimer's Disease, 0302 clinical medicine, Risk Factors, 80 and over, Ethnicity, Medicine, Longitudinal Studies, Aetiology, 10. No inequality, Aged, 80 and over, 0303 health sciences, Age Factors, Cognition, Middle Aged, Moderation, Female, Sex, medicine.medical_specialty, Genotype, Clinical Sciences, 03 medical and health sciences, Sex Factors, Clinical Research, Behavioral and Social Science, Acquired Cognitive Impairment, Genetics, Humans, Cognitive Dysfunction, Alleles, 030304 developmental biology, Aged, business.industry, Prevention, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, Carriage, THE JOURNAL OF GERONTOLOGY: Translational Section: Apoe: Biological and Clinical Insights on the Longevity Associated Gene, Dementia, Geriatrics and Gerontology, business, Gerontology, 030217 neurology & neurosurgery, Demography, 2.4 Surveillance and distribution
Abstract

We aimed to examine the relationship between Apolipoprotein E ε4 (APOE*4) carriage on cognitive decline, and whether these associations were moderated by sex, baseline age, ethnicity, and vascular risk factors. Participants were 19,225 individuals aged 54–103 years from 15 longitudinal cohort studies with a mean follow-up duration ranging between 1.2 and 10.7 years. Two-step individual participant data meta-analysis was used to pool results of study-wise analyses predicting memory and general cognitive decline from carriage of one or two APOE*4 alleles, and moderation of these associations by age, sex, vascular risk factors, and ethnicity. Separate pooled estimates were calculated in both men and women who were younger (ie, 62 years) and older (ie, 80 years) at baseline. Results showed that APOE*4 carriage was related to faster general cognitive decline in women, and faster memory decline in men. A stronger dose-dependent effect was observed in older men, with faster general cognitive and memory decline in those carrying two versus one APOE*4 allele. Vascular risk factors were related to an increased effect of APOE*4 on memory decline in younger women, but a weaker effect of APOE*4 on general cognitive decline in older men. The relationship between APOE*4 carriage and memory decline was larger in older-aged Asians than Whites. In sum, APOE*4 is related to cognitive decline in men and women, although these effects are enhanced by age and carriage of two APOE*4 alleles in men, a higher numbers of vascular risk factors during the early stages of late adulthood in women, and Asian ethnicity.

Published
2020
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