Search

Your search keyword '"Liang, Xiu-Ling"' showing total 2 results
Start Over "Liang, Xiu-Ling" Topic cognition
2 results on '"Liang, Xiu-Ling"'

1. G6 Behaviour problem of chinese huntington disease patients

Author

Wu Tengteng, Zeng Yixuan, Pei Zhong, Liang Xiu-ling, and Li Xunhua

Subjects
Proband, Pediatrics, medicine.medical_specialty, Chorea, Cognition, Disease, Irritability, Psychiatry and Mental health, Theory of mind, medicine, Anxiety, Surgery, Neurology (clinical), medicine.symptom, Psychiatry, Psychology, Depression (differential diagnoses)
Abstract

Aims To investigate the clinical manifestation, inherited pattern and the related factor of Chinese Huntington’s disease (HD) families. Methods The clinical data from 22 HD families was collected from 2013–2016. Patients (probands) received the genetic test and neurological evaluations including motor, cognitive and behaviour problem. Results 22 patients had the IT15 gene dynamic mutations, with the onset age ranged from 13 to 54. Typical chorea movements were always the first symptoms that were noticed. Irritability was the most common symptoms (77%) at a very early stage of the illness rather than depression or anxiety. Furthermore, impairment of the theory of mind (ToM) was also observed in these patients. Conclusions Chorea movement is the typical symptom of HD. Irritability is the most common behavioural symptom of these patients and may be linked to the ToM function.

Published
2016
Full Text
View/download PDF

2. Cognitive Impairment in Native Chinese with Spinocerebellar Ataxia Type 3.

Author

Feng, Li, Chen, Ding Bang, Hou, Le, Huang, Lin Huan, Lu, Shu Yang, Liang, Xiu Ling, and Li, Xun Hua

Subjects
MILD cognitive impairment, SPINOCEREBELLAR ataxia, PATIENTS, VERBAL behavior testing
Abstract

Background: Previous studies have shown cognitive impairment in patients with spinocerebellar ataxia type 3 (SCA3). However, there is a lack of data on Chinese patients with SCA3. Method: We investigated 22 native Chinese with SCA3 and 18 controls matched for age, education as well as mental status. Cognitive assessments were carefully carried out to measure verbal fluency, memory, attention, executive function, visuospatial and visuoconstructive functions. Results: The most common impairments of cognition in native Chinese with SCA3 were disruption of phonemic verbal fluency and frontal executive dysfunction. Deficits in semantic fluency were detected in about 31.8% patients. Impaired visuospatial function and verbal memory were also found in native Chinese with SCA3. The degree of ataxia, CAG repeat length and education were found to correlate with cognitive performance. Multivariate binary logistic regression suggested that an oculomotor disorder and depression are predictors of cognitive impairment. Conclusion: Native Chinese with SCA3 had cognitive impairment of frontal executive function, temporal and parietal functions. An oculomotor disorder might be an index of cognitive dysfunction. © 2014 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results