1. Cognitive Effects of White Matter Pathology in Normal and Pathological Aging.
- Author
-
Kaskikallio A, Karrasch M, Rinne JO, Tuokkola T, Parkkola R, and Grönholm-Nyman P
- Subjects
- Aged, Aged, 80 and over, Cerebrovascular Disorders diagnostic imaging, Cerebrovascular Disorders psychology, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Psychomotor Performance, Socioeconomic Factors, Aging psychology, Alzheimer Disease diagnostic imaging, Alzheimer Disease psychology, Cognition, Cognitive Dysfunction diagnostic imaging, Cognitive Dysfunction psychology, White Matter diagnostic imaging
- Abstract
We examined whether cerebrovascular white matter pathology is related to cognition as measured by the compound score of CERAD neuropsychological battery in cognitively normal older adults, patients with mild cognitive impairment, and patients with Alzheimer's disease (total n = 149), controlling for age and education. Trend-level effects of white matter pathology on cognition were only observed in patients with Alzheimer's disease (p = 0.062, η2 = 0.052), patients with severe frontal white matter pathology performed notably worse than those with milder pathology. This indicates that frontal cerebrovascular pathology may have an additive negative effect on cognition in Alzheimer's disease.
- Published
- 2019
- Full Text
- View/download PDF