1. A Network of Psychopathological, Cognitive, and Motor Symptoms in Schizophrenia Spectrum Disorders
- Author
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Moura, Bernardo Melo, van Rooijen, Geeske, Schirmbeck, Frederike, Wigman, Hanneke, Madeira, Luís, van Harten, Peter, van Os, Jim, Roberto Bakker, P., Marcelis, MacHteld, van Amelsvoort, Therese, Bartels-Velthuis, Agna A., Bruggeman, Richard, Cahn, Wiepke, Haan, Lieuwe De, Kahn, Rene S., Simons, Claudia J. P., Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), MUMC+: Hersen en Zenuw Centrum (3), MUMC+: MA Med Staf Spec Psychiatrie (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Adult Psychiatry, ANS - Complex Trait Genetics, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), and Clinical Cognitive Neuropsychiatry Research Program (CCNP)
- Subjects
Adult ,Male ,cognition ,Psychosis ,Palliative care ,Motor Disorders ,positive symptoms ,Cohort Studies ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Extrapyramidal symptoms ,PARKINSONS-DISEASE ,Rating scale ,5-FACTOR MODEL ,medicine ,Humans ,psychosis ,1ST-EPISODE PSYCHOSIS ,RATING-SCALE ,network analysis ,negative symptoms ,Positive and Negative Syndrome Scale ,ABNORMALITIES ,Cognition ,Regular Article ,IMPAIRMENT ,medicine.disease ,Corrigenda ,MIND ,030227 psychiatry ,extrapyramidal symptoms ,Psychiatry and Mental health ,Schizophrenia ,Female ,Schizophrenic Psychology ,medicine.symptom ,Psychology ,030217 neurology & neurosurgery ,NEGATIVE-SYNDROME-SCALE ,Clinical psychology ,Network analysis ,Psychopathology - Abstract
Schizophrenia spectrum disorders (SSDs) are complex syndromes involving psychopathological, cognitive, and also motor symptoms as core features. A better understanding of how these symptoms mutually impact each other could translate into diagnostic, prognostic, and, eventually, treatment advancements. The present study aimed to: (1) estimate a network model of psychopathological, cognitive, and motor symptoms in SSD; (2) detect communities and explore the connectivity and relative importance of variables within the network; and (3) explore differences in subsample networks according to remission status. A sample of 1007 patients from a multisite cohort study was included in the analysis. We estimated a network of 43 nodes, including all the items from the Positive and Negative Syndrome Scale, a cognitive assessment battery and clinical ratings of extrapyramidal symptoms. Methodologies specific to network analysis were employed to address the study’s aims. The estimated network for the total sample was densely interconnected and organized into 7 communities. Nodes related to insight, abstraction capacity, attention, and suspiciousness were the main bridges between network communities. The estimated network for the subgroup of patients in remission showed a sparser density and a different structure compared to the network of nonremitted patients. In conclusion, the present study conveys a detailed characterization of the interrelations between a set of core clinical elements of SSD. These results provide potential novel clues for clinical assessment and intervention.
- Published
- 2021