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An interview with Sorena Kiani, Consultant Immunologist at Barts Health National Health Service Trust, about the burden of the rare disease, hereditary angioedema, and recent clinical and real-world data presented at European Academy of Allergy and Clinical Immunology 2022. Whne asked about the pathophysiology of Hereditary Angioedema, he refers to a chronic, rare genetic disorder characterised by unpredictable severe, painful swelling attacks affecting skin or mucosa.