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Cardiac memory refers to T-wave inversions (TWI) on electrocardiograms (ECGs) after an episode of abnormal ventricular activation or wide electrical activity of ventricular muscles (QRS complex). We present the case of a 62-year-old woman with symptomatic bradycardia due to sinus pause. She immediately underwent temporary transvenous ventricular pacing. In the following days, intrinsic normal sinus rhythm was resumed at 69 bpm and a narrow QRS was observed (97 ms). Additionally, deep TWI was observed in leads II, III, aVF, and V3-V6. The distribution of TWI, normal echocardiogram and laboratory results, non-significant coronary angiogram, and recent right ventricular pacing correspond to possible cardiac T-wave memory. Follow-up 12-lead ECG four weeks later showed that T-wave morphology returned to normal baseline. This further confirmed the final diagnosis of cardiac memory-induced TWI. Recognizing cardiac memory-induced TWI is important for physicians to facilitate proper evaluation and management of TWI and prevent unnecessary further cardiac diagnostic tests. [ABSTRACT FROM AUTHOR]

Introduction: The novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has caused a pandemic. Many studies have shown that several laboratory parameters are related to disease severity and mortality in SARS‐CoV‐2 cases. This meta‐analysis aimed to determine the relationship of a prognostic factor, D‐dimer, with disease severity, need for intensive care unit (ICU) care, and mortality in SARS‐CoV‐2 patients. Methods: A systematic search for all observational studies and trials involving adult patients with SARS‐CoV‐2 that had any data related to D‐dimer on admission was conducted using PubMed, Science Direct, Scopus, ProQuest, and MedRxiv databases. We performed random‐effects inverse‐variance weighting analysis using mean difference (MD) of D‐dimer values for outcomes such as disease severity, mortality, and need for ICU care. Results: A total of 29 studies (4,328 patients) were included in this meta‐analysis, which revealed a higher mean of D‐dimer levels on admission in severe patients than in nonsevere patients (MD = 0.95, [95% confidence interval (CI): 0.61‐1.28], P <.05; I2 = 90%). The nonsurvivor group had a higher pooled MD of D‐dimer values on admission (MD = 5.54 [95% CI: 3.40‐7.67], P <.05; I2 = 90%). Patients who needed ICU admission had insignificantly higher D‐dimer values than patients who did not need ICU admission (MD = 0.29, [95% CI: −0.05 to 0.63], P =.10; I2 = 71%). Conclusion: Elevated D‐dimer levels on admission were associated with an increased risk of disease severity and mortality in patients with SARS‐CoV‐2 infection. [ABSTRACT FROM AUTHOR]