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Objective: To compare clinicopathological characteristics of patients with papillary thyroid carcinoma in association with the presence or absence of chronic lymphocytic thyroiditis in tertiary care hospital who underwent thyroidectomy. Material and Method: This was a cross sectional retrospective study carried out by the Department of pathology, NAMO Medical Institute of Medical Science, Silvassa. In the present study, histopathological record of patients who underwent for total thyroidectomy were reviewed NAMO Medical Institute of Medical Science, Shree Vinoba Bhave Hospital, Silvassa, during the period of December 2019- December 2022. Total 20 cases of thyroidectomy specimen with papillary carcinoma were included in the present study. Following variables were taken in the present study: Age and gender of patient, presence of chronic lymphocytic thyroditis, type of thyroid malignancy, tumor size and lymph node metastasis. The cancer other than papillary carcinoma and benign thyroid lesion were not included in the present study. Result: Total 200 Thyroidectomy were done within December 2019-december 2022 (3 years period), from which 170 (85%) cases were benign thyroid lesion which were excluded from the study. Only 30 (15%) cases were malignant thyroid lesion from which 20 (66.67%) cases were of papillary carcinoma of thyroid, 6 (20%) cases were of follicular carcinoma, 1 (3.33%) case was of medullar carcinoma, and 3 (10%) cases were others like lymphoma and poorly differentiated malignancy. Among the 20 patients, there were 16 (80%) men and 4 (20%) women. Mean age was 48.23+12.54 years. The mean tumor size was 2.5+0.97 cm. Based on univariate analysis, the mean age of patients with and without CLT was 40.45+10.64 and 46.6+11.18 years, respectively (P-value=0.143). Predominance of female gender was observed in patients without CLT compared to patients with CLT. The mean tumor size was smaller in patients with CLT than patients without CLT (1.7+0.88 cm vs 2.2+0.92 cm, respectively; P=0.033). Conclusion: The chronic lymphocytic Thyroiditis is positively associated with papillary carcinoma of Thyroiditis. The influence of Thyroiditis on prognosis of well differentiated thyroid epithelial malignancy needs to be evaluated on the larger sample size. [ABSTRACT FROM AUTHOR]