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Start Over Author "Kaarina Ranta" Topic clinical immunology
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1. Evaluation of immunostimulatory activities of synthetic mannose-containing structures mimicking the β-(1-2)-linked cell wall mannans of Candida albicans

Author

Monika Poláková, Reko Leino, Johannes Savolainen, Filip S. Ekholm, Mattias U. Roslund, Tiina Saloranta, Kaarina Ranta, and K. Nieminen

Subjects
Microbiology (medical), Clinical Biochemistry, Immunology, Disaccharide, Mannose, Peripheral blood mononuclear cell, Divalent, Microbiology, Mannans, chemistry.chemical_compound, Interferon-gamma, Mice, Candida albicans, medicine, Immunology and Allergy, Animals, Humans, Interferon gamma, Cells, Cultured, chemistry.chemical_classification, Mice, Inbred BALB C, biology, Tumor Necrosis Factor-alpha, Macrophages, biology.organism_classification, Molecular biology, In vitro, chemistry, Leukocytes, Mononuclear, Tumor necrosis factor alpha, Clinical Immunology, medicine.drug
Abstract

Immunostimulatory properties of synthetic structures mimicking the β-(1→2)-linked mannans ofCandida albicanswere evaluatedin vitro. Contrary to earlier observations, tumor necrosis factor (TNF) production was not detected after stimulation with mannotetraose in mouse macrophages. Divalent disaccharide 1,4-bis(α-d-mannopyranosyloxy)butane induced TNF and some molecules induced low levels of gamma interferon (IFN-γ) in human peripheral blood mononuclear cells (PBMC).

Published
2012

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