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Your search keyword '"Mohammed Alarifi"' showing total 2 results
Start Over Author "Mohammed Alarifi" Topic clinical characteristics
2 results on '"Mohammed Alarifi"'

1. Clinical and biochemical characteristics and outcomes of suspected COVID-19 hospitalized patients: RT-PCR swab positive and negative comparison

Author

Assim A. Alfadda, Mohammad AlKhowaiter, Naif Alotaibi, Khalid Alayed, Musa Alzahrani, Khalifa Binkhamis, Khalid Siddiqui, Amira Youssef, Haifa Altalhi, Ibrahim Almaghlouth, Mohammed Alarifi, Saleh Albanyan, Mohammed Faraj Alosaimi, Rana Hasanato, Arthur Isnani, Hafedh Dekhil, and Mohamed Rafiullah

Subjects
COVID-19, Clinical characteristics, Negative RT-PCR, Suspected COVID-19, Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270
Abstract

Background: COVID-19 is diagnosed using RT-PCR assays of samples from nasal and oropharyngeal swabs. People with negative RT-PCR often presented with clinical manifestations of COVID-19. The data on such patients are lacking. The present study aims to characterize the patients who were suspected COVID-19 cases and tested negative in RT-PCR compared to patients who had been tested RT-PCR positive. Methods: This is a retrospective, observational study of adult suspected and confirmed patients of COVID-19 admitted to King Saud University Medical City, Riyadh, Saudi Arabia, from 1st March 2020 until 30th November 2020. Laboratory confirmation is done through nasal/pharyngeal swab specimens, tested positive in RT-PCR assay. Patients with initial negative RT-PCR test results were assessed again within 48−72 h to avoid false-negative results. Patient data were extracted from the electronic medical files of each included patient using a predesigned case report form. Results: The study included 488 (80.93%) patients with RT-PCR swab results positive, and 115 (19.07%) patients who were negative. Respiratory rate and diastolic blood pressure were higher among the swab-positive cases. More number of swab-negative patients had comorbidities such as coronary heart disease, chronic kidney disease, and carcinoma. Fever, cough, and shortness of breath were reported higher among the swab-positive cases. ALT and AST, and LDH levels were found higher among RT-PCR-positive patients. Serum creatinine, blood urea nitrogen and troponin were more elevated in RT-PCR-negative patients. Antibiotics, anticoagulants, and corticosteroids were used more by swab-positive patients. Significantly higher number of RT-PCR-positive patients required proning, high-flow nasal cannula, non-invasive mechanical ventilation, and invasive mechanical ventilation. Acute cardiac ischemia and death were found to be similar among the patients. However, deaths occurred significantly earlier among the swab-positive cases when compared to the swab-negative group. Conclusion: Distinctive symptoms and markers of COVID-19 are more frequent among patients who had RT-PCR-positive results.

Published
2021
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2. Clinical and biochemical characteristics and outcomes of suspected COVID-19 hospitalized patients: RT-PCR swab positive and negative comparison

Author

Hafedh Dekhil, Mohammed Faraj Alosaimi, Khalid Siddiqui, Mohamed Rafiullah, Naif Alotaibi, Rana Hasanato, Haifa Altalhi, Assim A. Alfadda, Khalid Alayed, Ibrahim Almaghlouth, Saleh Albanyan, Arthur C. Isnani, Musa Alzahrani, Mohammed Alarifi, Mohammad AlKhowaiter, Amira M. Youssef, and Khalifa Binkhamis

Subjects
medicine.medical_treatment, ALP, Alkaline phosphatase, Infectious and parasitic diseases, RC109-216, Comorbidity, medicine.disease_cause, chemistry.chemical_compound, Suspected COVID-19, PTT, Partial thromboplastin time, Blood urea nitrogen, Case report form, Reverse Transcriptase Polymerase Chain Reaction, General Medicine, Hospitalization, ICU, Intensive care unit, Infectious Diseases, Original Article, Public aspects of medicine, RA1-1270, AST, Aspartate aminotransferase, SPSS, Statistical Package for the Social Sciences, Nasal cannula, BUN, Blood urea nitrogen, Adult, medicine.medical_specialty, SARS-CoV-2, Severe acute respiratory syndrome-coronavirus-2, BMI, Body mass index, COVID-19, Coronavirus disease-2019, INR, International normalised ratio, ACE-2, Angiotensin-converting enzyme-2, Internal medicine, ARDS, Acute respiratory distress syndrome, medicine, Carcinoma, Humans, CRP, C-Reactive protein, Mechanical ventilation, Creatinine, LDH, Lactate dehydrogenase, Clinical characteristics, business.industry, RT-PCR, Reverse-transcriptase polymerase chain reaction, SARS-CoV-2, Public Health, Environmental and Occupational Health, ALT, Alanine aminotransferase, Negative RT-PCR, COVID-19, CK, Creatine kinase, medicine.disease, GGT, Gamma-glutamyl transferase, CKD, Chronic kidney disease, PT, Prothrombin time, Blood pressure, chemistry, business, Kidney disease
Abstract

Background COVID-19 is diagnosed using RT-PCR assays of samples from nasal and oropharyngeal swabs. People with negative RT-PCR often presented with clinical manifestations of COVID-19. The data on such patients are lacking. The present study aims to characterize the patients who were suspected COVID-19 cases and tested negative in RT-PCR compared to patients who had been tested RT-PCR positive. Methods This is a retrospective, observational study of adult suspected and confirmed patients of COVID-19 admitted to King Saud University Medical City, Riyadh, Saudi Arabia, from 1st March 2020 until 30th November 2020. Laboratory confirmation is done through nasal/pharyngeal swab specimens, tested positive in RT-PCR assay. Patients with initial negative RT-PCR test results were assessed again within 48−72 h to avoid false-negative results. Patient data were extracted from the electronic medical files of each included patient using a predesigned case report form. Results The study included 488 (80.93%) patients with RT-PCR swab results positive, and 115 (19.07%) patients who were negative. Respiratory rate and diastolic blood pressure were higher among the swab-positive cases. More number of swab-negative patients had comorbidities such as coronary heart disease, chronic kidney disease, and carcinoma. Fever, cough, and shortness of breath were reported higher among the swab-positive cases. ALT and AST, and LDH levels were found higher among RT-PCR-positive patients. Serum creatinine, blood urea nitrogen and troponin were more elevated in RT-PCR-negative patients. Antibiotics, anticoagulants, and corticosteroids were used more by swab-positive patients. Significantly higher number of RT-PCR-positive patients required proning, high-flow nasal cannula, non-invasive mechanical ventilation, and invasive mechanical ventilation. Acute cardiac ischemia and death were found to be similar among the patients. However, deaths occurred significantly earlier among the swab-positive cases when compared to the swab-negative group. Conclusion Distinctive symptoms and markers of COVID-19 are more frequent among patients who had RT-PCR-positive results.

Published
2021

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