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Your search keyword '"Theodore Faust"' showing total 4 results
Start Over Author "Theodore Faust" Topic clinical biochemistry
4 results on '"Theodore Faust"'

1. Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties

Author

Ryan White, David C. Mcgowan, Xiaotian Zhu, Matthew W. Martin, John Newcomb, John L. Buchanan, Theodore Faust, Faye Hsieh, Xin Huang, Erin F. DiMauro, Susan M. Turci, Christina Boucher, Stephen Schneider, Joseph J. Nunes, Jean Bemis, and Josie H. Lee

Subjects
Pyridines, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Rats, Sprague-Dawley, Inhibitory Concentration 50, Structure-Activity Relationship, Pharmacokinetics, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Inhibitory concentration 50, Transferase, Amines, Protein Kinase Inhibitors, Molecular Biology, chemistry.chemical_classification, Chemistry, Organic Chemistry, In vitro, Rats, Enzyme, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Molecular Medicine
Abstract

2,3-Diarylfuro[2,3-b]pyridine-4-amines are a novel class of potent and selective inhibitors of Lck. The discovery, synthesis, and structure activity relationships of this series of inhibitors are reported. The most promising compounds were also profiled to deduce their pharmacokinetic properties.

Published
2007
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2. Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: development of an expedient and divergent synthetic route and preliminary SAR

Author

Alan C. Cheng, Ryan White, Stephen Schneider, Joseph J. Nunes, John L. Buchanan, Jean Bemis, Faye Hsieh, William H. Buckner, Susan M. Turci, Matthew W. Martin, Christina Boucher, John Newcomb, Xin Huang, Xiaotian Zhu, Josie H. Lee, Theodore Faust, Erin F. DiMauro, David C. Mcgowan, and Teresa L. Marshall

Subjects
Quantitative structure–activity relationship, Stereochemistry, Clinical Biochemistry, Anti-Inflammatory Agents, Pharmaceutical Science, Crystallographic data, Quantitative Structure-Activity Relationship, Biochemistry, Chemical synthesis, Rats, Sprague-Dawley, chemistry.chemical_compound, Inhibitory Concentration 50, Drug Discovery, Inhibitory concentration 50, Animals, Humans, Pharmacokinetics, Lymphocytes, Bifunctional, Molecular Biology, Protein Kinase Inhibitors, Chemistry, Organic Chemistry, Rats, Sprague dawley, Pyrimidines, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Molecular Medicine, Interleukin-2, Lymphocyte Culture Test, Mixed, Selectivity
Abstract

4-Amino-5,6-biaryl-furo[2,3-d]pyrimidines were identified as potent non-selective inhibitors of Lck. A novel, divergent, and practical synthetic route was developed to access derivatives from bifunctional intermediates. Lead optimization was guided by X-ray crystallographic data, and preliminary SAR led to the identification of compounds with improved cellular potency and selectivity.

Published
2006

3. Erratum to 'Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties' [Bioorg. Med. Chem. Lett. 17 (2007) 2299–2304]

Author

John Newcomb, John L. Buchanan, Susan M. Turci, Joseph J. Nunes, Xin Huang, Stephen Schneider, Ryan White, Faye Hsieh, Matthew W. Martin, Josie H. Lee, Xiaotian Zhu, David C. Mcgowan, Christina Boucher, Jean Bemis, Erin F. DiMauro, and Theodore Faust

Subjects
Pharmacokinetics, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Biochemistry
Published
2007
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4. Erratum to 'Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: Development of an expedient and divergent synthetic route and preliminary SAR' [Bioorg. Med. Chem. Lett. 17 (2007) 2305–2309]

Author

Ryan White, Joseph J. Nunes, Josie H. Lee, Matthew W. Martin, Jean Bemis, Susan M. Turci, David C. Mcgowan, Xiaotian Zhu, Christina Boucher, Teresa L. Marshall, Stephen Schneider, John L. Buchanan, Alan C. Cheng, Xin Huang, John Newcomb, Erin F. DiMauro, Theodore Faust, William H. Buckner, and Faye Hsieh

Subjects
Stereochemistry, Chemistry, Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Biochemistry, Combinatorial chemistry
Published
2007
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