1. [Continuous, low dosage estradiol administration with a vaginal ring: a placebo-controlled study].
- Author
-
Casper F, Petri E, and Benninghoff B
- Subjects
- Delayed-Action Preparations, Double-Blind Method, Estradiol adverse effects, Female, Humans, Middle Aged, Treatment Outcome, Climacteric drug effects, Estradiol administration & dosage, Estrogen Replacement Therapy instrumentation, Pessaries
- Abstract
Unlabelled: Estrogen replacement therapy is used in postmenopausal women with symptoms of urogenital atrophy. The aim of this study was to detect differences in efficacy of a low-dose estradiol-releasing vaginal ring and a placebo ring in the relief of symptoms of estrogen deficiency and reduction of urogenital atrophy (pH and vaginal mucosal maturation) in postmenopausal women., Design: This was a multicentre double-blind, placebo-controlled study., Patient Sample: 84 postmenopausal women, of whom 67 completed the full 24 weeks of treatment., Results: Vaginal pH decreased significantly (p = 0.0006) in the estradiol group compared with the placebo group. Similarly, in the estradiol group the mean maturation value increased significantly (p = 0.0004), while incidence of pallor and friability were significantly reduced. Patients in the estradiol group reported significantly greater relief of dyspareunia., Conclusion: The results indicate that the estradiol-releasing vaginal ring is effective and well tolerated in the treatment of local estrogen deficiency.
- Published
- 1998