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Currently, tomato is one of the most cultivated crops worldwide, with the highest economic value, increasing its demand and, thus, its expansion, production, and trade. The tomato crop is susceptible to attack of pathogens with devastating consequences on the decline in yields from 50 to 100%. For this reason, new production methods are proposed such as grafting in wild rootstocks, which have high genetic variability and genes responsible for resistance to fungi, bacteria, viruses, and nematodes. The aim of this study was to evaluate the effect of grafting commercial tomato cultivars onto cherry tomato genotypes on yield and fruit quality. The experiment was arranged in a completely randomized design with four replications. The experimental unit consisted of four plants. spaced at 0.9 m between rows (channels), 0.30 m between double rows, and 0.4 m between plants. The treatments consisted of the combination of the following factors: three promising rootstocks (IAC391, IAC426, and LA2076), two commercial scions (Calima and Torrano), two grafting methods (cleft and splice), and two ungrafted commercial controls. Yield components, soluble solids content, percentage of fruit quality, and average fruit weight were evaluated. IAC391 was the most promising rootstock, reaching productions similar to those of the controls. The cleft grafting method, reached a success rate of 98.3%. The commercial scion Torrano stood out for achieving the highest yields. [ABSTRACT FROM AUTHOR]