1. The activation of nuclear factor-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling blunts cholestasis-induced liver and kidney injury
- Author
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Ram Kumar Manthari, Zhipeng Jia, Hossein Niknahad, Yangfei Zhao, Khadijeh Mousavi, Bahman Khalvati, Yuanyu Chen, Mohammad Mehdi Ommati, Reza Heidari, Negar Azarpira, Xiong Shi, Huifeng Li, and Asrin Ahmadi
- Subjects
Paper ,medicine.medical_specialty ,Kidney ,Cirrhosis ,business.industry ,Health, Toxicology and Mutagenesis ,Toxicology ,medicine.disease ,medicine.disease_cause ,Nephropathy ,Heme oxygenase ,Endocrinology ,medicine.anatomical_structure ,Cholestasis ,Fibrosis ,Internal medicine ,Toxicity ,Medicine ,business ,Oxidative stress - Abstract
Cholestasis is a severe clinical complication that severely damages the liver. Kidneys are also the most affected extrahepatic organs in cholestasis. The pivotal role of oxidative stress has been mentioned in the pathogenesis of cholestasis-induced organ injury. The activation of the nuclear factor-E2-related factor 2 (Nrf2) pathway is involved in response to oxidative stress. The current study was designed to evaluate the potential role of Nrf2 signaling activation in preventing bile acids-induced toxicity in the liver and kidney. Dimethyl fumarate was used as a robust activator of Nrf2 signaling. Rats underwent bile duct ligation surgery and were treated with dimethyl fumarate (10 and 40 mg/kg). Severe oxidative stress was evident in the liver and kidney of cholestatic animals (P
- Published
- 2021