1. Higher Liver Stiffness Predicting Adverse Outcomes in Cirrhotic Patients with Child-Pugh Grades A and B
- Author
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Li Tao, Ye Qian, Wang Lei, Liu Jiaye, Lin Chunlei, and Qu Yundong
- Subjects
Liver Cirrhosis ,Hepatitis B virus ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Cirrhosis ,Every Six Months ,business.industry ,Liver Neoplasms ,General Medicine ,medicine.disease ,medicine.disease_cause ,Liver stiffness ,Hepatocellular carcinoma ,Internal medicine ,Cohort ,medicine ,Humans ,Observational study ,Prospective Studies ,Prospective cohort study ,business - Abstract
OBJECTIVE To describe the baseline characteristics and two-year outcomes of patients with Child-Pugh grades A and B cirrhosis; and evaluate the predictive value of liver stiffness for the development of adverse outcomes (AOs) in this patient population. STUDY DESIGN A prospective cohort study. PLACE AND DURATION OF STUDY The Second Hospital, Cheeloo College of Medicine, Shandong University, China between September 2018 and March 2021. METHODOLOGY The present study consecutively included patients with Child-Pugh grades A and B cirrhosis. Patients were followed up every six months until two years. Baseline demographic characteristics and laboratory indexes were collected. Liver stiffness and controlled attenuation parameter were measured at baseline, month 6 and month 12. The observational endpoint was AOs, including liver-related patient death and hepatocellular carcinoma (HCC). RESULTS A total of 174 patients were included in the final cohort. Hepatitis B virus (HBV)-induced liver cirrhosis accounted for the vast majority of enrolled cases (82.2%). AOs were observed in six patients. Multivariate logistic regression model was performed and liver stiffness was considered as the only independent predictor for AOs (OR 1.071, p = 0.006). Liver stiffness was also significantly improved at 12 months compared with the baseline data (median 10.6 vs. 13.3 kPa, p
- Published
- 2021