1. Long-term clinical outcomes of cardiac resynchronization therapy with or without defibrillation:impact of the aetiology of cardiomyopathy
- Author
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Zegard, A., Umar, F., Taylor, R.j., Acquaye, E., Gubran, C., Chalil, S., Patel, K., Panting, J., Marshall, H., and Leyva-Leon, Francisco
- Subjects
genetic structures ,cardiovascular system ,cardiovascular diseases ,equipment and supplies ,circulatory and respiratory physiology - Abstract
Background: There is a continuing debate as to whether cardiac resynchronization therapy-defibrillation (CRT-D) is superior to CRT-pacing (CRT-P), particularly in patients with non-ischemic cardiomyopathy (NICM). Objective: We sought to quantify clinical outcomes after primary prevention CRT-D and CRT-P and whether clinical outcomes differ according to the etiology of cardiomyopathy. Methods: Clinical events were quantified in patients undergoing CRT-D (n = 551) or CRT-P (n = 999). Analyses were undertaken in the total study population and in propensity-matched samples. Device choice was governed by clinical guidelines in the United Kingdom. Results: In univariable analyses of the total study population, (maximum follow-up: 16 years; median of 4.7 years (interquartile range [IQR]: 2.4-7.1), CRT-D was associated with a lower total mortality (HR:0.71) and the composite endpoints of total mortality or HF hospitalization (HR:0.72) and total mortality or hospitalization for major adverse cardiac events (MACE; HR:0.71) (all p
- Published
- 2017