1. Effects of transcranial direct current stimulation on symptoms of nicotine dependence: A systematic review and meta-analysis.
- Author
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Kang N, Kim RK, and Kim HJ
- Subjects
- Cigarette Smoking physiopathology, Cigarette Smoking psychology, Craving, Cues, Humans, Tobacco Use Disorder physiopathology, Tobacco Use Disorder psychology, Cigarette Smoking therapy, Prefrontal Cortex, Tobacco Use Disorder therapy, Transcranial Magnetic Stimulation methods
- Abstract
The purpose of this systematic review and meta-analysis was to investigate the effects of transcranial direct current stimulation (tDCS) on symptoms of nicotine dependence in treatment-seeking smokers. Twelve studies qualified for this meta-analysis, and we used 15 total comparisons from the included studies for the data synthesis. Primary outcome measures were changes in (a) cue-provoked craving and (b) smoking intake (i.e., the number of cigarettes smoked) between active tDCS stimulation and sham control groups. Random-effects model meta-analyses revealed significant positive effects of tDCS on seven cue-provoked craving comparisons (effect size = 0.422; P = .004) and eight smoking intake comparisons (effect size = 0.557; P = .004). Moderator variable analyses indicated that applying anodal-tDCS on the right dorsolateral prefrontal cortex (DLPFC) revealed significant positive effects on the cue-provoked craving with minimal heterogeneity. Further, applying cathodal-tDCS on DLPFC regions showed more positive effects on both cue-provoked craving and smoking intake than cathodal-tDCS on other brain regions. These findings suggested that tDCS modulating DLPFC activity can be an effective option for decreasing individual's smoking dependence symptoms., (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Published
- 2019
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