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The purpose of the research was to analyze the effectiveness of the therapy SynflorixTM” vaccine in the conservative complex treatment of chronic tonsillitis in children. Material and method. The clinical study included 68 children with uncomplicated chronic tonsillitis who were divided into two groups: 1-34 children undergoing treatment with the vaccine „SynflorixTM” concomitantly with standard therapy; Lot 2 - 34 children receiving standard therapy (tonsil gaps washing with antiseptic solution sprinkling tonsils Lugol solution). Immunological investigations were carried out before and after three months of treatment, which included: the functional activity of T cells and specific sensitivity of cells; CD16 lymphocyte content; phagocytic ability of neutrophils; the level of circulating immune complexes (CIC); Complement hemolytic activity (AHTC); titer content cytokines IL-8, IL-1β, TNF-α, IL-4. Results. CIC levels really decreased after treatment only in children from group 1 (p<0.01, to treatment - 290 ± 27; after - 187 ± 16.2), in group 2 was observed only a downward trend. In children from the first group, the increase phagocytic activity of neutrophils was more robust (p<0.001, up - 4.2 ± 0.14 after - 5.2 ± 0.19) compared with children from Lot 2 (p <0.05 by - 4.7 ± 0.27; after - 5.3 ± 0.18). Dynamic content in CD-16 treatment was really increased only in children from the first group (p <0.01, up -14.6 ± 0.28 ± 0.23 after -15.8). Post-treatment, the AHTC remained truthful highest in children from Lot 1, compared with children from Lot 2 (p <0.05, 60.4 ± 1.36; 55.8 ± 1.42). The functional activity of T lymphocytes in dynamics conclusive treatment increased more in children of group 1 (p<0.001, 65.9 ± 0.70, 68.4 ± 0.65), than those from group 2 (p<0, 05 66.8 ± 0.79, 69.2 ± 0.67). The titer of Streptococcus antigens and T lymphocytes increased after treatment only in children from group 1 (p<0.05, 3.5 ± 0.30, 4.2 ± 0.16). Proinflammatory cytokine, TNF-α, reduced after treatment more significantly in group 1 (p<0.001, 1.5 ± 0.1, 0.7 ± 0.08) compared with group 2 (p<0.05, 1.5 ± 0.13, 1.0 ± 0.16). The levels of IL-8 and IL-1β cytokine tended to decrease after treatment in both groups. The titres of anti-inflammatory cytokine IL-4 were higher after treatment in children from group 1, than those from group 2 (p<0.05, 21 ± 1.19; 15.8 ± 2.17). The number of acute upper respiratory tract infection really decreased over 2 years in group 2 (p<0.001 by the treatment - 5.7 ± 0.18 by - 1.3 ± 0.42). In group 1, the decrease was less significant (6.4 ± 0.30, 2.8 ± 0.32). Post-treatment, the number of antibiotic therapy prescriptions dropped more truthful in children of group1. Conclusion. The vaccine „SynflorixTM” normalizes the immune reactivity of children with chronic tonsillitis and has a positive clinical effect at a high level. [ABSTRACT FROM AUTHOR]