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Introduction: Chronic rhinosinusitis (CRS) is a common condtion in the world leading to a significant burden on society in term of healthcare comsumption and productivity loss result in Quality of Life (QoL). The pathogenesis of CRS has not been fully eludicated. Increased inflammation and decreased number and/or impaired function of T regulatory cell (Tregs) has been reported. Based on EPOS the pharmacology treatment of CRS management is amoxicilin-clavulanic acid. Objective: To determine the efficacy of amoxicilinclavulanic acid treatment in decreasing the disease severity, reducing nasal symtomps, increasing Tregs and improvement QoL. Materials and Methods: A prospective cohort study, with comparative pre and posttest design in 25 samples. Subjects was treated with nasal irrigation solution (NaCl 0.9%), corticosteroid nasal spray, and amoxicillin-clavulanic acid for 1 month. The severity of the disease was assessed Visual Analog Scale (VAS), nasoendoscopic score by Lund and Kennedy. Quality of Life using Sinonasal Outcome Test-22 (SNOT- 22). Tregs cell and Mean Fluorescence Intensity (MFI) by flowcytometry. Results: A total of 25 patients were include with a mean age of 30.5±96.8 years. On the 1 month after treatment found reducing of VAS (p<0.05) except for loss of smell (p=0.063), nasoendoscopic score (p<0.05), SNOT-22 (p<0,05) except for psychological domain (p=0.212). Level of T-Reg total (p=0,814), and level MFI T-Reg (p=0,388) showed no significant increase after 1 month amoxicilin-clavulanic acid treatment. Conclusion: Amoxicillin-clavulanic acid treatment in CRS patients significantly improved nasal symtomps, QoL, but does not increased levels of regulatory T-cell. [ABSTRACT FROM AUTHOR]