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Objective To explore the influential factors of pulmonary function in patients with chronic obstructive pulmonary disease （COPD） in Kunming district. Methods A total of 300 patients with COPD were selected from 5 tertiary hospitals in Kunming district as subjects investigated. The subjects were investigated by self-designed questionnaire， and then the influential factors of patients with COPD were analyzed. Results By linear correlation analysis, there were positive correlation between each of degree of education, economic income , the number of quitting smoking and percentage of the forced expiratory volume in one second divided by the predicted value （ FEV1% pre） （r values respectively were 0.318， 0.309， 0.113，P values respectively were 0.000， 0.000， 0.05）， there were negative correlation between smoking index， tobacco dependence score and FEV1%pre （r values respectively were -0.202，-0.323，P values respectively were 0.000，0.000） . By multiple linear regression analysis，FEV1% pre=34.792-1.765 x tobacco dependence score+2.558xdegree of education+2. 587×economic income， in the nine influential factors （gender，age，body mass index， degree of education， economic income，smoking index，whether to give up smoking，number of quitting smoking， tobacco dependence score）， the tobacco dependence score was the main factor affecting FEV1% pre. Conclusions The higher the degree of education，economic income of the patients with COPD have，the longer number of years of the patients with COPD quit smoking，the lower smoking index and tobacco dependence score tobacco dependence score have， the higher the FEV1%pre of the patients with COPD have. The tobacco dependence score is the main factor affecting FEV1%pre. [ABSTRACT FROM AUTHOR]

Objective To observe the effects of transplantation of mesenehymal stem cells (MSCs) on pathological changes of rats with pulmonary emphysema and changes in levels of inflammatory factors in the serum and lung tissues. Methods Twenty-four female SD rats were randomly divided into three groups: the control group, emphysema group and trans-plantation group, 8 per group. Rat models of emphysema were established by fumigation in the emphysema group and trans-plantation group. Rats in the control group were fed routinely. MSCs were injected into recipient rats of transplantation group. Eight weeks after transplantation of MSCs, lung fissure sections were made to study the morphological alterations, mean alveolar numbers (MAN) and mean linear intercept (MLI) were calculated. The inflammatory factors in the serum and lung tissues were analyzed by using protein chip technique and differently expressed inflammatory factors were screened. Results In the transplantation group, 8 weeks after transplantation, MSCs can be observed in the lung tissues. Emphysematous changes of lung tissues were observed in both emphysema group and transplantation group. Emphysematous changes in transplantation group were more serious than that of the emphysema group. Significant difference was found in MLI and MAN of lung tissues in the transplantation group as compared with that of the other two groups (all P<0.05). The differently expressed inflammatory factors were ciliary neurotrophic factor (CNTF), nerve growth factor (NGF), IL-10, activin A, chemokine CX3 and leptin in the lung tissues between the emphysema group and control group;and the differently expressed inflammatory factors were CNTF, IL-10 and TNF-α in the lung tissues between the transplantation group and emphysema group. The levels of CNTF in the lung tissues were statistically different among these three groups (all P<0.05). The differently expressed inflammatory factors in the serum were CNTF, IL-1β, IL-2, IL-4 and IL-6 between the emphysema group and control group; and the differently expressed inflammatory factors in the serum were IL-1β, IFN-γand IL-10 between the transplantation group and the emphysema group.The levels of IL-1β were statistically different among these three groups (all P<0.05). Conclusions MSCs transplantation can effectively alleviates the pathological changes of pulmonary emphysema in rat models, whose mechanism may be involved in down-regulating the expression of inflammatory factor. [ABSTRACT FROM AUTHOR]