1. Serum Levels of Annexin A2 as a Candidate Biomarker for Hepatic Fibrosis in Patients With Chronic Hepatitis B.
- Author
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Kolgelier, Servet, Demir, Nazlim Aktug, Inkaya, Ahmet Cagkan, Sumer, Sua, Ozcimen, Serap, Demir, Lutfi Saltuk, Pehlivan, Fatma Seher, Arslan, Mahmure, and Arpaci, Abdullah
- Subjects
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BIOMARKERS , *CHI-squared test , *ENZYME-linked immunosorbent assay , *STATISTICS , *DATA analysis , *FIBROSIS , *DATA analysis software , *DESCRIPTIVE statistics , *CHRONIC hepatitis B , *MANN Whitney U Test , *KRUSKAL-Wallis Test - Abstract
Background: Hepatologists have studied serologic markers of liver injury for decades. Annexins are a prominent group of such markers and annexin A2 (AnxA2) is one of the best characterized annexins. AnxA2 inhibits HBV polymerase among other functions. Its expression is up-regulated in regenerative hepatocytes. Objectives: To determine if serum AnxA2 level has a role in estimating liver damage in chronic HBV infection and investigate whether AnxA2 levels correlate with hepatic fibrosis. Patients and Methods: This study included 173 patients with chronic hepatitis B (CHB) and 51 healthy controls. Liver fibrosis was graded histologically on liver biopsy samples. Blood samples were taken from patients during biopsy and serum AnxA2 levels were measured with ELISA. Results: In a group of adult patients with CHB, AnxA2 values were far higher than those of the control group (P = 0.001). When we assessed AnxA2 levels based on fibrosis stages, serum AnxA2 levels of patients with early stage fibrosis (stages 1 - 3) were significantly higher than those of patients with advanced stage fibrosis (stages 4 - 5; P = 0.001). Conclusions: AnxA2 is a useful biomarker for early stage fibrosis in patients with CHB. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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