1. Motor ability, function, and health-related quality of life as correlates of symptom burden in patients with sclerotic chronic graft-versus-host disease receiving imatinib mesylate
- Author
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Rosenthal, Emily A, Ho, Pei-Shu, Joe, Galen O, Mitchell, Sandra A, Booher, Susan, Pavletic, Steven Z, Baird, Kristin, Cowen, Edward W, and Comis, Leora E
- Subjects
Adult ,Male ,Adolescent ,Health-related quality of life ,Clinical Trials and Supportive Activities ,Graft vs Host Disease ,Medical and Health Sciences ,Young Adult ,Clinical Research ,Humans ,Clinical Trials ,Oncology & Carcinogenesis ,Child ,Sclerosis ,Phase II as Topic ,Rehabilitation ,Psychology and Cognitive Sciences ,Middle Aged ,Chronic graft-versus-host disease ,Brain Disorders ,Physical Rehabilitation ,Good Health and Well Being ,Functional impairment ,Motor Skills ,Chronic Disease ,Allogeneic hematopoietic stem cell transplantation ,Quality of Life ,Imatinib Mesylate ,Symptom burden ,Female - Abstract
PurposeTo explore improvement in motor ability, function, health-related quality of life (HRQOL), and symptom severity in patients with sclerotic chronic graft-versus-host disease (ScGVHD) in response to treatment as well as the relationship among changes on such measures.MethodsThis study was a secondary analysis of data from 13 individuals with severe ScGVHD enrolled in a clinical trial evaluating the efficacy of imatinib mesylate (clinicaltrials.gov identifier: NCT00702689). Self-reported, clinician-reported, and performance-based indicators of motor ability, function, HRQOL, and symptom severity were assessed at baseline and 6months following the administration of imatinib mesylate.ResultsParticipants did not show statistically significant improvement on any measures over time. Approximately one-third of patients displayed clinically significant improvement on measures of motor ability (palmar pinch strength, dominant hand, 30.8%), functioning (Manual Ability Measure-36, 41.7%), HRQOL (Short Form 36 [SF-36] Mental Component Summary, 33.3%), and symptom severity (Lee Symptom Scale, 38.5%). Improvement in cGVHD symptom burden was correlated with improvement in function (Assessment of Motor and Process Skills [AMPS] and Disabilities of the Arm, Shoulder, and Hand [DASH] scores) and HRQOL (SF-36 Physical Component Summary scores).ConclusionsFindings suggest the potential utility of administering patient-reported and performance-based functional measures, such as the DASH and the AMPS, to patients with cGVHD. By understanding the functional consequences of ScGVHD, interdisciplinary teams of health care providers, including rehabilitation professionals, can work to improve long-term outcomes.
- Published
- 2020