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1. Mutations in the coding region of the insulin promoter factor 1 gene are not a common cause of maturity-onset diabetes of the young in Japanese subjects.

Author

Hara, Manami, Lindner, Tom H., Paz, Veronica P., Wang, Xiaoyu, Iwasaki, Naoko, Ogata, Makiko, Iwamoto, Yasuhiko, Bell, Graeme I., Hara, M, Lindner, T H, Paz, V P, Wang, X, Iwasaki, N, Ogata, M, Iwamoto, Y, and Bell, G I

Subjects
PROMOTERS (Genetics), TYPE 2 diabetes, CHROMOSOMES, CLINICAL trials, COMPARATIVE studies, DOCUMENTATION, GENES, RESEARCH methodology, MEDICAL cooperation, GENETIC mutation, PROTEINS, RESEARCH, EVALUATION research
Abstract

Examines the role of mutations in the coding region of the insulin promoter factor 1 gene in maturity-onset diabetes of young Japanese. Feature of all forms of diabetes; Pancreatic beta cell dysfunction caused by either immune-mediated beta-cell destruction in type 1 diabetes or failure of the beta cell to compensate to meet the increasing demand for insulin.

Published
1998
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