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Your search keyword '"Wenzlaff, Angie"' showing total 3 results
Start Over Author "Wenzlaff, Angie" Topic chromosomes, human, pair 15
3 results on '"Wenzlaff, Angie"'

1. Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25.

Author

Chen LS, Saccone NL, Culverhouse RC, Bracci PM, Chen CH, Dueker N, Han Y, Huang H, Jin G, Kohno T, Ma JZ, Przybeck TR, Sanders AR, Smith JA, Sung YJ, Wenzlaff AS, Wu C, Yoon D, Chen YT, Cheng YC, Cho YS, David SP, Duan J, Eaton CB, Furberg H, Goate AM, Gu D, Hansen HM, Hartz S, Hu Z, Kim YJ, Kittner SJ, Levinson DF, Mosley TH, Payne TJ, Rao DC, Rice JP, Rice TK, Schwantes-An TH, Shete SS, Shi J, Spitz MR, Sun YV, Tsai FJ, Wang JC, Wrensch MR, Xian H, Gejman PV, He J, Hunt SC, Kardia SL, Li MD, Lin D, Mitchell BD, Park T, Schwartz AG, Shen H, Wiencke JK, Wu JY, Yokota J, Amos CI, and Bierut LJ

Subjects
Adolescent, Adult, Black or African American, Aged, Aged, 80 and over, Asian People, Black People, Female, Gene Frequency, Genetics, Population, Humans, Lung Diseases etiology, Lung Diseases genetics, Lung Neoplasms etiology, Lung Neoplasms genetics, Male, Middle Aged, Odds Ratio, Phenotype, Risk, White People, Chromosomes, Human, Pair 15, Genetic Variation, Smoking adverse effects
Abstract

Recent meta-analyses of European ancestry subjects show strong evidence for association between smoking quantity and multiple genetic variants on chromosome 15q25. This meta-analysis extends the examination of association between distinct genes in the CHRNA5-CHRNA3-CHRNB4 region and smoking quantity to Asian and African American populations to confirm and refine specific reported associations. Association results for a dichotomized cigarettes smoked per day phenotype in 27 datasets (European ancestry (N = 14,786), Asian (N = 6,889), and African American (N = 10,912) for a total of 32,587 smokers) were meta-analyzed by population and results were compared across all three populations. We demonstrate association between smoking quantity and markers in the chromosome 15q25 region across all three populations, and narrow the region of association. Of the variants tested, only rs16969968 is associated with smoking (P < 0.01) in each of these three populations (odds ratio [OR] = 1.33, 95% CI = 1.25-1.42, P = 1.1 × 10(-17) in meta-analysis across all population samples). Additional variants displayed a consistent signal in both European ancestry and Asian datasets, but not in African Americans. The observed consistent association of rs16969968 with heavy smoking across multiple populations, combined with its known biological significance, suggests rs16969968 is most likely a functional variant that alters risk for heavy smoking. We interpret additional association results that differ across populations as providing evidence for additional functional variants, but we are unable to further localize the source of this association. Using the cross-population study paradigm provides valuable insights to narrow regions of interest and inform future biological experiments., (© 2012 Wiley Periodicals, Inc.)

Published
2012
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2. Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium.

Author

Truong T, Hung RJ, Amos CI, Wu X, Bickeböller H, Rosenberger A, Sauter W, Illig T, Wichmann HE, Risch A, Dienemann H, Kaaks R, Yang P, Jiang R, Wiencke JK, Wrensch M, Hansen H, Kelsey KT, Matsuo K, Tajima K, Schwartz AG, Wenzlaff A, Seow A, Ying C, Staratschek-Jox A, Nürnberg P, Stoelben E, Wolf J, Lazarus P, Muscat JE, Gallagher CJ, Zienolddiny S, Haugen A, van der Heijden HF, Kiemeney LA, Isla D, Mayordomo JI, Rafnar T, Stefansson K, Zhang ZF, Chang SC, Kim JH, Hong YC, Duell EJ, Andrew AS, Lejbkowicz F, Rennert G, Müller H, Brenner H, Le Marchand L, Benhamou S, Bouchardy C, Teare MD, Xue X, McLaughlin J, Liu G, McKay JD, Brennan P, and Spitz MR

Subjects
Adenocarcinoma ethnology, Adenocarcinoma genetics, Adult, Aged, Aged, 80 and over, Canada epidemiology, Carcinoma, Large Cell ethnology, Carcinoma, Large Cell genetics, Carcinoma, Small Cell ethnology, Carcinoma, Small Cell genetics, Carcinoma, Squamous Cell ethnology, Carcinoma, Squamous Cell genetics, Case-Control Studies, Europe, Female, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Homozygote, Humans, International Cooperation, Japan epidemiology, Korea epidemiology, Linkage Disequilibrium genetics, Lung Neoplasms etiology, Male, Middle Aged, Odds Ratio, Quality Control, Risk Assessment, Risk Factors, Singapore epidemiology, Smoking genetics, United States epidemiology, Asian People genetics, Chromosomes, Human, Pair 15, Chromosomes, Human, Pair 5, Chromosomes, Human, Pair 6, Lung Neoplasms ethnology, Lung Neoplasms genetics, Polymorphism, Single Nucleotide, Smoking adverse effects, Tobacco Use Disorder ethnology, Tobacco Use Disorder genetics, White People genetics
Abstract

Background: Genome-wide association studies have identified three chromosomal regions at 15q25, 5p15, and 6p21 as being associated with the risk of lung cancer. To confirm these associations in independent studies and investigate heterogeneity of these associations within specific subgroups, we conducted a coordinated genotyping study within the International Lung Cancer Consortium based on independent studies that were not included in previous genome-wide association studies., Methods: Genotype data for single-nucleotide polymorphisms at chromosomes 15q25 (rs16969968, rs8034191), 5p15 (rs2736100, rs402710), and 6p21 (rs2256543, rs4324798) from 21 case-control studies for 11 645 lung cancer case patients and 14 954 control subjects, of whom 85% were white and 15% were Asian, were pooled. Associations between the variants and the risk of lung cancer were estimated by logistic regression models. All statistical tests were two-sided., Results: Associations between 15q25 and the risk of lung cancer were replicated in white ever-smokers (rs16969968: odds ratio [OR] = 1.26, 95% confidence interval [CI] = 1.21 to 1.32, P(trend) = 2 x 10(-26)), and this association was stronger for those diagnosed at younger ages. There was no association in never-smokers or in Asians between either of the 15q25 variants and the risk of lung cancer. For the chromosome 5p15 region, we confirmed statistically significant associations in whites for both rs2736100 (OR = 1.15, 95% CI = 1.10 to 1.20, P(trend) = 1 x 10(-10)) and rs402710 (OR = 1.14, 95% CI = 1.09 to 1.19, P(trend) = 5 x 10(-8)) and identified similar associations in Asians (rs2736100: OR = 1.23, 95% CI = 1.12 to 1.35, P(trend) = 2 x 10(-5); rs402710: OR = 1.15, 95% CI = 1.04 to 1.27, P(trend) = .007). The associations between the 5p15 variants and lung cancer differed by histology; odds ratios for rs2736100 were highest in adenocarcinoma and for rs402710 were highest in adenocarcinoma and squamous cell carcinomas. This pattern was observed in both ethnic groups. Neither of the two variants on chromosome 6p21 was associated with the risk of lung cancer., Conclusions: In this international genetic association study of lung cancer, previous associations found in white populations were replicated and new associations were identified in Asian populations. Future genetic studies of lung cancer should include detailed stratification by histology.

Published
2010
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3. Smoking and Genetic Risk Variation across Populations of European, Asian, and African-American Ancestry - A Meta-analysis of Chromosome 15q25

Author

Chen, Li-Shiun, Saccone, Nancy L., Culverhouse, Robert C., Bracci, Paige M., Chen, Chien-Hsiun, Dueker, Nicole, Han, Younghun, Huang, Hongyan, Jin, Guangfu, Kohno, Takashi, Ma, Jennie Z., Przybeck, Thomas R., Sanders, Alan R., Smith, Jennifer A., Sung, Yun Ju, Wenzlaff, Angie S., Wu, Chen, Yoon, Dankyu, Chen, Ying-Ting, Cheng, Yu-Ching, Cho, Yoon Shin, David, Sean P., Duan, Jubao, Eaton, Charles B., Furberg, Helena, Goate, Alison M., Gu, Dongfeng, Hansen, Helen M., Hartz, Sarah, Hu, Zhibin, Kim, Young Jin, Kittner, Steven J., Levinson, Douglas F., Mosley, Thomas H., Payne, Thomas J., Rao, DC, Rice, John P., Rice, Treva K., Schwantes-An, Tae-Hwi, Shete, Sanjay S., Shi, Jianxin, Spitz, Margaret R., Sun, Yan V., Tsai, Fuu-Jen, Wang, Jen C., Wrensch, Margaret R., Xian, Hong, Gejman, Pablo V., He, Jiang, Hunt, Steven C., Kardia, Sharon L., Li, Ming D., Lin, Dongxin, Mitchell, Braxton D., Park, Taesung, Schwartz, Ann G., Shen, Hongbing, Wiencke, John K., Wu, Jer-Yuarn, Yokota, Jun, Amos, Christopher I., and Bierut, Laura J.

Subjects
Adult, Aged, 80 and over, Lung Diseases, Male, Risk, Chromosomes, Human, Pair 15, Lung Neoplasms, Adolescent, Smoking, Black People, Genetic Variation, Middle Aged, Article, White People, Black or African American, Genetics, Population, Phenotype, Asian People, Gene Frequency, Odds Ratio, Humans, Female, Aged
Abstract

Recent meta-analyses of European ancestry subjects show strong evidence for association between smoking quantity and multiple genetic variants on chromosome 15q25. This meta-analysis extends the examination of association between distinct genes in the CHRNA5-CHRNA3-CHRNB4 region and smoking quantity to Asian and African American populations to confirm and refine specific reported associations. Association results for a dichotomized cigarettes smoked per day phenotype in 27 datasets (European ancestry (N = 14,786), Asian (N = 6,889), and African American (N = 10,912) for a total of 32,587 smokers) were meta-analyzed by population and results were compared across all three populations. We demonstrate association between smoking quantity and markers in the chromosome 15q25 region across all three populations, and narrow the region of association. Of the variants tested, only rs16969968 is associated with smoking (P0.01) in each of these three populations (odds ratio [OR] = 1.33, 95% CI = 1.25-1.42, P = 1.1 × 10(-17) in meta-analysis across all population samples). Additional variants displayed a consistent signal in both European ancestry and Asian datasets, but not in African Americans. The observed consistent association of rs16969968 with heavy smoking across multiple populations, combined with its known biological significance, suggests rs16969968 is most likely a functional variant that alters risk for heavy smoking. We interpret additional association results that differ across populations as providing evidence for additional functional variants, but we are unable to further localize the source of this association. Using the cross-population study paradigm provides valuable insights to narrow regions of interest and inform future biological experiments.

Published
2012

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