Search

A patient with a constitutional chromosomal abnormality who developed acute nonlymphocytic leukemia (ANLL-M4) at the age of 31 is presented. At the time of diagnosis the only acquired chromosomal change was the presence of a small marker chromosome. The patient was studied periodically for 11 years during his illness with no evidence of karyotypic progression, until the last study, when a deletion of the long arm of chromosome 7 was detected.

The case of 50-years-old woman with the chronic type of erythraemia (di Guglielmo syndrome) and the karyotype 45, XX, --11,2q+ of bone marrow cells is described. By means of G-banding the karyotype 45,XX, -2, -11, + der (2), t(2;11) (2pter leads to 2qter:: 11q12 leads to 11qter) was established. The karyotype of bone marrow was thus partically monosomic for chromosome No. 11, for its segment 11 (pter leads to q11).