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2 results on '"Zhang, Li-Qin"'

1. Two new 13-hydroxylated milbemycin metabolites from the genetically engineered strain Streptomyces avermitilis AVE-H39.

Author

Wang, Ji-Dong, Qi, Huan, Zhang, Ji, Li, Jian-Song, Zhang, Shao-Yong, Hao, Zhi-Kui, Zhang, Li-Qin, and Xiang, Wen-Sheng

Subjects
ORGANIC compound analysis, NEMATODE infections, INSECTICIDES, ORGANIC compounds, NUCLEAR magnetic resonance spectroscopy, HYDROXYLATION, GENETIC engineering, MASS spectrometry, RESEARCH funding, MOLECULAR structure, CHROMATOGRAPHIC analysis, METABOLITES, FERMENTATION, GRAM-positive bacteria
Abstract

Two new milbemycin metabolites, 13α-hydroxymilbemycin β13 (1) and 26-methyl-13α-hydroxymilbemycin β13 (2), were isolated from the fermentation broth of a genetically engineered strain Streptomyces avermitilis AVE-H39. Their structures were determined by the comprehensive spectroscopic data, including 1 D, 2 D NMR, MS spectral analysis and the comparison with data from the literature. Compounds 1 and 2 not only exhibited potent acaricidal activities against Tetranychus cinnabarinus, but also had nematocidal activity against Bursaphelenchus xylophilus. [ABSTRACT FROM AUTHOR]

Published
2021
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2. Two new milbemycin derivatives from a genetically engineered strain Streptomyces bingchenggensis.

Author

Li, Jian-Song, Qi, Huan, Zhang, Shao-Yong, Xiang, Wen-Sheng, Zhang, Li-Qin, Wang, Hai-Yan, Hao, Zhi-Kui, and Wang, Ji-Dong

Subjects
NEMATODE infections, CULTURE media (Biology), GENETIC engineering, RESEARCH funding, MOLECULAR structure, CHROMATOGRAPHIC analysis, CELL separation, GRAM-positive bacteria, MACROLIDE antibiotics, BACTERIA, FERMENTATION, CENTRIFUGATION
Abstract

Two new milbemycin derivatives, milbemycin M (1) and milbemycin N (2), were isolated from the culture of a genetically engineered strain Streptomyces bingchenggensis BCJ60. Their structures were elucidated through the interpretation of NMR and HR-ESI-MS spectroscopic data, as well as comparison with previous reports. The acaricidal and nematicidal activities of them against Tetranychus cinnabarinus and Bursaphelenchus xylophilus were tested. The results showed that compounds 1–2 possessed potent acaricidal and nematocidal activities. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
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