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Your search keyword '"Shchegoleva IV"' showing total 2 results
Start Over Author "Shchegoleva IV" Topic choroidal neovascularization
2 results on '"Shchegoleva IV"'

1. [Influence of genetic mutations on clinical presentation of subretinal neovascularization. Report 1: The impact of CFH and IL-8 genes polymorphism].

Author

Budzinskaia MV, Pogoda TV, Generozov ÉV, Chikun EA, Shchegoleva IV, Kazarian ÉÉ, and Galoian NS

Subjects
Adult, Aged, Aged, 80 and over, Chorioretinitis complications, Choroid blood supply, Complement Inactivating Agents, Female, Fluorescein Angiography, Humans, Macular Degeneration complications, Male, Middle Aged, Mutation, Myopia, Degenerative complications, Neovascularization, Pathologic etiology, Neovascularization, Pathologic genetics, Neovascularization, Pathologic pathology, Polymorphism, Single Nucleotide, Radiography, Retinal Vessels pathology, Risk Factors, Subretinal Fluid diagnostic imaging, Chorioretinitis genetics, Choroidal Neovascularization etiology, Choroidal Neovascularization genetics, Choroidal Neovascularization pathology, Choroidal Neovascularization physiopathology, Complement Factor H genetics, Genetic Predisposition to Disease, Interleukin-8 genetics, Macular Degeneration genetics, Myopia, Degenerative genetics
Abstract

Genetic analysis was performed in patients with subretinal neovascularization (CNV). The results showed significant association of CFH (compliment factor H) gene polymorphism with increase (rs1061170, rs514943 and rs380390) or decrease (rs529825, rs7524776, rs1831281, rs2274700, rs1576340, rs12144939, rs7540032) of CNV development risk. The incidence of IL-8 gene mutation was significantly (p = 0.008) higher in patients after chorioretinitis. Apparently -125 > A polymorphism in patients with chorioretinitis increases risk of CNV development, thus promoting raise of proangiogenic factors concentration in eyes with inflammatory background. The clinical presentation in patients with AMD and myopic disease associated with (-125) A mutation of promoter region of IL-8 gene was similar to that of patients with chorioretinitis. The features are the following: focal pattern, no drusen and RPE detachment, predominantly classic form of CNV (without occult pattern), formation of well-organized newly developed vessels.

Published
2011

2. [Influence of genetic mutations on clinical presentation of subretinal neovascularization. Report 2: The impact of HTRA and VEGF genes polymorphism].

Author

Budzinskaia MV, Pogoda TV, Strelkova ID, Chikun EA, Shchegoleva IV, Kazarian ÉÉ, and Galoian NS

Subjects
Choroid blood supply, Complement Factor H genetics, Female, Fluorescein Angiography, Genetic Predisposition to Disease, Humans, Interleukin-8 genetics, Macular Degeneration complications, Male, Middle Aged, Myopia, Degenerative complications, Neovascularization, Pathologic genetics, Retinal Vessels pathology, Visual Acuity, Choroidal Neovascularization etiology, Choroidal Neovascularization genetics, Choroidal Neovascularization pathology, Choroidal Neovascularization physiopathology, Macular Degeneration genetics, Mutation, Myopia, Degenerative genetics, Polymorphism, Single Nucleotide, Serine Endopeptidases genetics, Vascular Endothelial Growth Factor A genetics
Abstract

A detailed analysis of influence of HTRA (serine peptidase) and VEGF (vascular endothelial growth factor) genes mutations is presented. The presence of one gene copy with allele of A- polymorphism rs1120638 of HTRA1 gen, T- polymorphism rs10490924 and de11443in54 of ARMS2 gene increases the risk of CNV in patients with AMD. The feature of clinical presentation in patients with CNV associated with (-625) A mutation of promoter region of HTRA1 gene in two chromosomes was fulminant course of the disease from exudative to scarring processes with fibrous tissue formation not just with sub-, but also intra- and preretinal localization. Genetic screening showed that combination of studied mutations (402H, (-625) A and (-251) A in both gene copies of CFH, HTRA and IL-8) results in the most severe and rapidly progressing form of the disease. Two new mutations were revealed in promoter region of VEGF gene: G > A replacement in position of (-72) nucleotide from transcription start and G > A replacement in 5'-nontranslated region of the 1st gene exon in position of (+31) nucleotide from transcription start.

Published
2011

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