1. Choroidal structural changes in different intermediate AMD patterns.
- Author
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Viggiano P, Toto L, Ferro G, Evangelista F, Porreca A, and Mastropasqua R
- Subjects
- Cross-Sectional Studies, Fluorescein Angiography, Humans, Prospective Studies, Tomography, Optical Coherence, Choroid diagnostic imaging, Retinal Drusen diagnostic imaging
- Abstract
Purpose: To report variation of choroidal thickness (CT) and choroidal vascularity index (CVI) in subjects with drusen and subjects with reticular pseudodrusen (RPD) compared with healthy individuals using the Spectral-domain (SD)-Optical Coherence Tomography with enhanced depth imaging (EDI) system., Design: A prospective, observational, cross-sectional study., Subjects: Eighty-four participants., Methods: The patients were imaged using the Heidelberg Spectralis device (Heidelberg Engineering, Heidelberg, Germany) with EDI mode. EDI-OCT images were exported and then imported into image analysis ImageJ software (National Institutes of Health, Bethesda) and a semiautomated algorithm was used for subsequent quantitative analysis., Main Outcome Measures: This study evaluated two choroidal parameters: (i) choroidal thickness (CT); (ii) choroidal vascularity index (CVI)., Results: CT analysis was performed in three different regions: (i) foveal region, (ii) parafoveal region; (iii) perifoveal region. All the analyzed regions were significantly decreased in RPD pattern, as compared with both the drusen group ( p < .005) and healthy eyes ( p < .005). CVI was significantly decreased in the RPD pattern, as compared with healthy eyes ( p < 0.001). However, the drusenoid pattern did not have statistical significance in comparison with the control group suggesting the lower incidence of this pattern on choroidal vasculopathy., Conclusions: We report CT and CVI difference in RPD and drusen eyes. The RPD pattern seems to be a consequence of an alteration in the choroidal vascularity resulting in severe ischemia and excessive hypoxia inducing an increased risk of late AMD compared to the drusenoid pattern.
- Published
- 2022
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