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Purpose: This study aims to assess the disparities in choroidal thickness and optic disc parameters between individuals diagnosed with chronic gout and an age- and gender-matched control cohort., Methods: This cross-sectional study involved 30 gout patients receiving treatment at the Rheumatology clinic, alongside 30 healthy control individuals matched for age and gender. A comprehensive ophthalmological assessment, encompassing visual acuity measurement, intraocular pressure evaluation, slit-lamp biomicroscopy, and dilated fundus examination, was conducted for all participants. Peripapillary retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), and subfoveal choroidal thickness (SFCT) were quantified utilizing Spectral Domain Optical Coherence Tomography., Results: The mean age within the study group was 54.53 ± 9.43 years, while the control group's mean age was 53.20 ± 10.36 years. In both the gout and control cohorts, there were 28 men and 2 women. No significant differences were observed in age and gender between the groups. Gout patients manifested thinner RNFL and GCC across all quadrants; however, statistically significant thinning was only evident in the nasal and inferior quadrants for RNFL. Despite a thinner SFCT observed in gout patients compared to controls, this discrepancy did not attain statistical significance., Conclusion: Chronic phase gout patients may display alterations in optic disc and macular parameters, alongside potential variations in choroidal thickness. Nevertheless, more controlled studies encompassing a larger participant pool are imperative to substantiate our findings., (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)

Objectives: To report changes in the choroid, optic nerve, and macula in diabetes mellitus patients without diabetic retinopathy, and to compare these findings with age and sex-matched healthy volunteers. Furthermore, the duration of the disease was recorded and the impact on these parameters was aimed to be analyzed. Methods: In this study, 60 right eyes of diabetes mellitus (DM) patients without diabetic retinopathy who applied to our department for routine examination were enrolled. To evaluate the peripapillary retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL), Swept-Source Optical Coherence Tomography imaging was performed. In addition, images were recorded and processed by the image-j program and the ‘choroidal vascularity index’ (CVI) was calculated. The measurements were compared with 60 right eyes of age-sex-matched healthy volunteers. Furthermore, the patient group was divided into 2 subgroups according to disease duration and the measurements were compared with each other as well. Results: Both RNFL and GCL thickness values were observed to be thinner in DM patients group compared to the control group. CVI was found to be lower in DM group compared to the control group. In addition, the duration of the disease was significantly associated with the RNFL and GCL thinning and lower CVI. Conclusion: DM can lead to a decrease in RNLF and GCL thickness and also a decrease in CVI which can impair visual acuity even in the absence of diabetic retinopathy. Therefore, monitoring changes in the optic nerve, retina, and choroid layer is crucial in these patients. [ABSTRACT FROM AUTHOR]