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2 results on '"Whiting GC"'

1. Streptococcus pneumoniae choline binding proteins. Role in cell wall turnover.

Author

Whiting GC and Gillespie SH

Subjects
Bacterial Proteins genetics, Bacterial Proteins isolation & purification, Base Sequence, Carrier Proteins genetics, Carrier Proteins isolation & purification, DNA Primers genetics, DNA, Bacterial genetics, DNA, Bacterial isolation & purification, Humans, Lipopolysaccharides metabolism, N-Acetylmuramoyl-L-alanine Amidase genetics, N-Acetylmuramoyl-L-alanine Amidase isolation & purification, Streptococcal Infections etiology, Streptococcus pneumoniae genetics, Streptococcus pneumoniae pathogenicity, Teichoic Acids metabolism, Virulence, Bacterial Proteins metabolism, Carrier Proteins metabolism, Cell Wall metabolism, Choline metabolism, N-Acetylmuramoyl-L-alanine Amidase metabolism, Streptococcus pneumoniae metabolism
Published
1997

2. Incorporation of choline into Streptococcus pneumoniae cell wall antigens: evidence for choline kinase activity.

Author

Whiting GC and Gillespie SH

Subjects
Base Sequence, Cell Wall immunology, Cell Wall metabolism, Choline Kinase genetics, DNA Primers genetics, DNA, Bacterial genetics, Genes, Bacterial, Genes, Fungal, Lipopolysaccharides biosynthesis, Lipopolysaccharides immunology, Molecular Sequence Data, Saccharomyces cerevisiae enzymology, Saccharomyces cerevisiae genetics, Streptococcus pneumoniae genetics, Teichoic Acids biosynthesis, Teichoic Acids immunology, Antigens, Bacterial metabolism, Choline metabolism, Choline Kinase metabolism, Streptococcus pneumoniae immunology, Streptococcus pneumoniae metabolism
Abstract

The choline-containing teichoic and lipoteichoic acids play an important part in cell wall metabolism of Streptococcus pneumoniae. We propose that a choline kinase enzyme has a role in the synthesis of these antigens. The presence of this enzyme was demonstrated in cell free extracts of S. pneumoniae by measuring the fall in ATP concentration due to phosphorylation of choline. Genomic DNA of S. pneumoniae hybridised with a probe consisting of an internal fragment of the choline kinase gene of Saccharomyces cerevisiae and one consisting of the choline binding domain of lytA.

Published
1996
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