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The effect of some deep eutectic solvents (DESs) on the coumarin solubility has been investigated using Hansen solubility parameters (HSP). The solubility of coumarin was measured in aqueous systems containing some DESs based on choline chloride (ChCl) as hydrogen bond acceptor (HBA) with urea (U), ethylene glycol (EG), and glycerol (GLY) as hydrogen bond donors (HBD) by widely applied shake-flask method at T = (298.15 to 313.15) K. The results indicate that coumarin solubility enhances with the concentration of DESs and temperature. Also, coumarin was dissolved more than 80 times compared with pure water in the presence of ChCl/EG. Then experimental data were fitted to Wilson, electrolyte Non-Random Tow-Liquid (e-NRTL), and UNIQUAC activity coefficient models. Furthermore, the dissolution thermodynamic properties including enthalpy, Gibbs free energy, and entropy have been calculated based on Gibbs and van't Hoff equations. Due to these results, it is indicated that coumarin dissolution in the studied systems is an endothermic process. Moreover, to investigate the biological properties of DESs, MTT assay have been applied to determinate cytotoxicity of the DESs. In the melanoma skin cell line, cell culture tests revealed that these solvents had very low toxicity and high biocompatibility., (Copyright © 2021 Elsevier B.V. All rights reserved.)

Naproxen (NAP) is a widely used drug for the treatment of pain and inflammatory conditions. However, there is not the physicochemical information about this drug such as solubility, volumetric and compressibility properties in the presence of deep eutectic solvents (DES) as a new class of green solvents to overcome the low solubility of drugs. In this work, the solubility of NAP is studied in the solutions containing some choline chloride (ChCl) based DES at temperature ranges (298.15-313.15) K. The results indicate that the solubility increases with increasing the concentration of DES and temperature and DES containing malonic acid is the proper co-solvent. The experimental solubility values were correlated by the e-NRTL, Wilson and UNIQUAC models. In addition, the complex interactions between the components in the systems should be elucidated, therefore, the thermodynamic properties including volumetric and compressibility properties have been investigated using density and speed of sound measurements at T = 298.15 K. According to calculated thermodynamic parameters, strong interactions between NAP and DESs are observed which is in agreement with obtained solubility data., (Copyright © 2019 Elsevier B.V. All rights reserved.)

Deep eutectic solvents (DESs) as a new class of green solvents have been used to overcome the low solubility of drugs during the recent years. In this work, the effect of some DESs containing choline chloride as hydrogen bond acceptor and urea, oxalic acid and malonic acid as hydrogen bond donors have been studied on acetaminophen (ACP) solubility at temperature ranges (298.15 to 313.15) K. The results indicate that the solubility of ACP increase with increasing concentration of DES and at higher temperatures and the DES containing malonic acid have a greater impact on the solubility of acetaminophen. The solubility data were correlated by the modified Apelblat, λh (Buchowski) and Yalkowsky models which Apelblat model is more consistent with experimental data. In addition, to elucidate the interactions between the components, the thermodynamic properties including volumetric, compressibility properties have been investigated using density and speed of sound measurements at T=(288.15 to 318.15K). The calculated thermodynamic parameters values confirm the strong solute - solvent interactions between ACP - DESs that is in agreement with solubility data., (Copyright © 2017 Elsevier B.V. All rights reserved.)