1. RIP140 triggers foam-cell formation by repressing ABCA1/G1 expression and cholesterol efflux via liver X receptor.
- Author
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He Y, Zhang L, Li Z, Gao H, Yue Z, Liu Z, Liu X, Feng X, and Liu P
- Subjects
- ATP Binding Cassette Transporter 1 genetics, ATP Binding Cassette Transporter, Subfamily G, Member 1, ATP-Binding Cassette Transporters genetics, Cell Line, Gene Expression, Gene Silencing, Humans, Lipoproteins, LDL physiology, Liver X Receptors, Nuclear Receptor Interacting Protein 1, ATP Binding Cassette Transporter 1 metabolism, ATP-Binding Cassette Transporters metabolism, Adaptor Proteins, Signal Transducing physiology, Cholesterol metabolism, Foam Cells physiology, Nuclear Proteins physiology, Orphan Nuclear Receptors metabolism
- Abstract
Receptor-interacting protein 140 (RIP140) is a multifunctional coregulator of lipid metabolism and inflammation. However, the potential role of RIP140 in atherosclerosis remains unknown. The present study investigated the impact of RIP140 on foam cell formation, a critical step in pathogenesis of atherosclerosis. The expression of RIP140 was increased in foam cells. RIP140 overexpression resulted in decreased cholesterol efflux in macrophages and their concomitant differentiation into foam cells. Moreover, RIP140 negatively regulated the macrophage expression of ATP-binding cassette transporters A1 and G1 (ABCA1/G1), by suppressing the expression and activity of liver X receptor (LXR). These findings shed light onto the contribution of RIP140 to the development and progression of atherosclerosis, and suggest a novel therapeutic target for the treatment of atherosclerosis., (Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.)
- Published
- 2015
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