1. Intracerebroventricular leptin regulates hepatic cholesterol metabolism.
- Author
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Vanpatten S, Karkanias GB, Rossetti L, and Cohen DE
- Subjects
- Animals, Cerebral Ventricles, Cholesterol blood, Cholesterol 7-alpha-Hydroxylase metabolism, Hydroxymethylglutaryl CoA Reductases metabolism, Infusions, Intravenous, Infusions, Parenteral, Leptin administration & dosage, Lipids blood, Lipoproteins blood, Liver drug effects, Male, Rats, Rats, Sprague-Dawley, Cholesterol metabolism, Leptin pharmacology, Liver metabolism
- Abstract
To elucidate the control of hepatic cholesterol metabolism by leptin, rats were administered IV (intravenous) leptin, ICV (intracerebroventricular) leptin or saline. A single low dose of ICV leptin was as effective as a continuous IV infusion of high-dose leptin at decreasing the activities of 3-hydroxy-3-methylglutaryl-CoA reductase and cholesterol 7alpha-hydroxylase. These results indicate that the hepatic response to leptin is transduced via the central nervous system.
- Published
- 2004
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