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Cholestasis is a multifactorial disorder with various biological, infectious, toxic, genetic and metabolic manifestations, its principal feature presented as reduced bile flow or abnormalities in bile formation. It has lately been accepted that some specific biological markers would shorten the period needed to establish a positive diagnosis, as currently it is necessary to navigate through a complex diagnostic protocol for this disorder. The purpose of this study was to establish some biological parameters and biomarkers useful for cholestasis management in children. Two hundred thirty-two children with cholestasis were selected, during a six-year study. The biological indicators followed were serum bilirubin, gamma-glutamyl transpeptidase, aspartate transaminase, alkaline phosphatase, lactate dehydrogenase, serum cholesterol and triglycerides. Our data showed that certain biological parameters are more often involved in the various forms of cholestasis, and the conclusions of this study could be useful in the early detection of cholestasis and appropriate disease management. [ABSTRACT FROM AUTHOR]

Neonatal hepatitis represents an often met pediatric pathology. In order to determine a diagnosis multiple investigations are required, to rule out other pathologies associated with cholestasis or even associated to neonatal hepatitis, which might alter the therapeutic formula and the prognosis of the disease. The study aim to underline the importance of early identification of the cholestasis and it's objective manifestations through a detailed protocole. Material and method: 293 children were screened, admitted for various conditions that could generate intra- or extrahepatic cholestasis. Results: Neonatal hepatitis is one of the main pathologies involved in the occurrence of cholestasis in young age. The most frequent etiology is the infectious one, most cases being engendered by the cytomegalic virus. Using a previously designed algorithm we could determine a diagnosis earlier, and we could also evaluate the systemic echo of the cholestasis. Conclusions: For an early, clearcut diagnosis, a previously designed diagnosis protocol must be acquired in the case of a child with cholestasis, as neonatal hepatitis represents a significant proportion of the children with cholestasis. [ABSTRACT FROM AUTHOR]