1. [The role of biliary decompression and correction of dysbiosis in the treatment of obstructive jaundice].
- Author
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Lipnitskiĭ EM, Gal'perin ÉI, Kotovskiĭ AE, Chzhao AV, Istratov VG, and Bekbauov SA
- Subjects
- Cholangitis etiology, Cholangitis metabolism, Cholangitis physiopathology, Cholestasis etiology, Cholestasis metabolism, Cholestasis physiopathology, Combined Modality Therapy, Decompression, Surgical adverse effects, Humans, Jaundice, Obstructive complications, Jaundice, Obstructive metabolism, Jaundice, Obstructive physiopathology, Jaundice, Obstructive therapy, Postoperative Complications mortality, Sorption Detoxification adverse effects, Bacterial Translocation physiology, Cholangitis microbiology, Cholestasis microbiology, Endotoxins blood, Gastrointestinal Contents microbiology, Hepatic Insufficiency metabolism, Hepatic Insufficiency microbiology, Hepatic Insufficiency physiopathology, Jaundice, Obstructive microbiology
- Abstract
The article providing in-depth analysis of pathogenesis of obstructive jaundice shows that this disease is manifest not only as changes at the hepatic level (cholestasis, cholehemia, cholangitis, cholangio- and lymphovenous shunts, hepatic encephalopathy) but also as marked dysbiotic disturbances due to anacholia and toxic metabolites that cause bacterial translocation and endotoxemia complicating liver insufficiency. Based on the literary data and original observations, a new scheme for the treatment of obstructive jaundice is proposed including simultaneous correction of both components of hepatoenteric turnover, also, it permits to improve the outcome of the postoperative period.
- Published
- 2010