1. Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp.
- Author
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Mun B, Wang W, Kim H, Hahn D, Yang I, Won DH, Kim EH, Lee J, Han C, Kim H, Ekins M, Nam SJ, Choi H, and Kang H
- Subjects
- Animals, Antineoplastic Agents isolation & purification, Antineoplastic Agents pharmacology, Cell Line, Tumor, Dose-Response Relationship, Drug, Humans, Molecular Structure, Sterols toxicity, Cholestadienols isolation & purification, Cholestadienols pharmacology, Cholestenes isolation & purification, Cholestenes pharmacology, Norsteroids isolation & purification, Norsteroids pharmacology, Porifera chemistry, Sterols isolation & purification, Sterols pharmacology
- Abstract
Three new sterols, 5α,8α-epidioxy-24-norcholesta-6,9(11),22-trien-3β-ol (1), 5α,8α-epidioxy-cholesta-6,9(11),24-trien-3β-ol (2), and 5α,8α-epidioxy-cholesta-6,23-dien-3β,25-diol (3), with four known sterols (4-7) were isolated from a marine sponge Monanchora sp. Their chemical structures were elucidated by extensive spectroscopic analysis. Compounds 1 and 3-7 showed moderate cytotoxicity against several human carcinoma cell lines including renal (A-498), pancreatic (PANC-1 and MIA PaCa-2), and colorectal (HCT 116) cancer cell lines.
- Published
- 2015
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