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Unregulated use of chlorpyrifos (CPF) and monocrotophos (MCP) in agriculture casts adverse effects on non-target freshwater mollusc, Pila globosa and humans. Levels of CPF and MCP were assessed in the paddy field from the edible foot tissue of apple snail (Pila globosa) exposed to low (1.5 ml l -1 water) and high (2.5 ml l -1 water) agricultural doses for 48 h to determine human health risk associated with consumption of tissue. CPF and MCP were extracted by liquid-liquid extraction and analysed by QuEChERS method using GC-MS/MS. For low and high concentrations of CPF exposure, the pesticide residue levels in the paddy field water ranged from 4.43 to 1.08 and 5.13 to 1.53 µg l -1 , respectively, whereas, for low and high concentrations of MCP exposure, the residue levels in water ranged from 16.43 to 5.78 and 31.41 to 9. 27 µg l -1 , respectively, for 3-48 h. In the foot tissue, residues ranged from 4.36 to 15.54 µg kg -1 for low-dose CPF, 7.1 to 18.05 µg kg -1 for high-dose CPF and from 5.28 to 12.3 µg kg -1 and 8.94 to 18.21 µg kg -1 for low and high dose of MCP, respectively, during 3 to 48 h of exposure. Pesticides in the tissue were lower than the recommended maximum residue limits. Estimated health risk for adults and children revealed that the estimated daily intake values did not exceed the threshold values of acceptable daily intake. Non-carcinogenic and carcinogenic health effects were less than the safe value of 1.0 and 1 × 10 -6 , respectively, suggesting that CPF and MCP residues from ingestion of apple snail posed low risks to both children and adults. This preliminary result suggests regular monitoring of pesticides residues in Pila globosa collected from the paddy field of India., (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)