1. Development of chlorine dioxide sustained-release device using carboxymethyl cellulose-polyvinyl alcohol-β-cyclodextrin ternary hydrogel and a new sustained-release kinetic model.
- Author
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Wang, Yanan, Zhao, Hanyu, Huang, Lijie, Chen, Guangxue, Wei, Zhehao, Mo, Qi, Li, Yishan, Wang, Xiyue, Huang, Chongxing, and Chen, Qifeng
- Subjects
CHLORINE dioxide ,CYCLODEXTRINS ,SAFETY factor in engineering ,CARBOXYMETHYLCELLULOSE - Abstract
Owing to unique physiochemical and biological properties as well as the ability to be combined with a wide variety of materials for both biocompatibility and hydrophilia, carboxymethyl cellulose (CMC) is an excellent choice as a carrier. Loading Chlorine dioxide (ClO
2 ) into biodegradable carrier for its good disinfection performance and high safety factors has attracted significantattention. Therefore, in this study, we used ClO2 as a model drug, and a sustained-ClO2 -gas-release gel was developed from degradable materials, such as carboxymethyl cellulose (CMC), polyvinyl alcohol (PVA), and β-cyclodextrin (βCD), through a simple and benign crosslinking strategy. Notably, the gel had sustained-release property in a wide temperature range of 4–35 ℃ and released ClO2 gas effectively for more than 30 days. Furthermore, a loss factor was proposed based on the incomplete release of the drug in the sustained release process to a chieve a good fit with the gas diffusion process. A new diffusion model was designed based on the Korsmeyer–Peppas model, and an excellent fit was obtained. This sustained-ClO2 -gas-release gel provides theoretical and technical guidance for the development of sustained-disinfectant-release agents for use in space and offers new insights into the sustained release model of skeleton-soluble hydrogels. [ABSTRACT FROM AUTHOR]- Published
- 2023
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