1. Near-Infrared Light-Triggered Chlorine Radical ( . Cl) Stress for Cancer Therapy.
- Author
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Song R, Wang H, Zhang M, Liu Y, Meng X, Zhai S, Wang CC, Gong T, Wu Y, Jiang X, and Bu W
- Subjects
- Animals, Antineoplastic Agents chemistry, Cell Line, Tumor, Cell Proliferation drug effects, Cell Survival drug effects, Chlorine chemistry, Drug Screening Assays, Antitumor, Female, Free Radicals chemistry, Infrared Rays, Mammary Neoplasms, Experimental drug therapy, Mammary Neoplasms, Experimental metabolism, Mammary Neoplasms, Experimental pathology, Mice, Nanoparticles chemistry, Oxidative Stress drug effects, Particle Size, Photosensitizing Agents chemistry, Silicon Dioxide chemistry, Silicon Dioxide pharmacology, Silver chemistry, Silver pharmacology, Surface Properties, Antineoplastic Agents pharmacology, Chlorine pharmacology, Free Radicals pharmacology, Photosensitizing Agents pharmacology
- Abstract
Free radicals with reactive chemical properties can fight tumors without causing drug resistance. Reactive oxygen species (ROS) has been widely used for cancer treatment, but regrettably, the common O
2 and H2 O2 deficiency in tumors sets a severe barrier for sufficient ROS production, leading to unsatisfactory anticancer outcomes. Here, we construct a chlorine radical (. Cl) nano-generator with SiO2 -coated upconversion nanoparticles (UCNPs) on the inside and Ag0 /AgCl hetero-dots on the outside. Upon near-infrared (NIR) light irradiation, the short-wavelength emission UCNP catalyzes. Cl generation from Ag0 /AgCl with no dependence on O2 /H2 O2 .. Cl with strong oxidizing capacity and nucleophilicity can attack biomolecules in cancer cells more effectively than ROS. This. Cl stress treatment will no doubt broaden the family of oxidative stress-induced antitumor strategies by using non-oxygen free radicals, which is significant in the development of new anticancer agents., (© 2020 Wiley-VCH GmbH.)- Published
- 2020
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