1. Remote Selective C−H Halogenation of Arylphosphine Oxides with Ferric Halides.
- Author
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Yu, Hong, Lin, Xiuhua, Xu, Guang, Yin, Tingrui, Zhang, Ying, Liu, Jinpeng, Chen, Jian, Meng, Sixuan, Yuan, Jia, Dang, Li, and Yu, Guang‐Ao
- Subjects
HALOGENATION ,HALIDES ,PHOSPHINE oxides ,IRON chlorides ,PHOSPHINES - Abstract
We developed the remote selective C−H bromination for the synthesis of C4′‐brominated biarylphosphine oxides using FeBr3 as a brominating reagent. C3′‐Brominated products were obtained in reactions with substrates bearing a 2,4,6‐triisopropyl substituent on the bottom ring. Moreover, direct access to C5‐chlorinated peri‐substituted(1‐naphthalenyl)phosphines is developed using FeCl3 as a chlorinating reagent. These halogenated compounds can be utilized for cross‐coupling reactions to construct functionalized phosphine oxides. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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