1. A unidirectional water-transport antibacterial bilayer nanofibrous dressing based on chitosan for accelerating wound healing.
- Author
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Wu H, Gao B, Wu H, Song J, Zhu L, Zhou M, Linghu X, Huang S, Zhou Z, and Wa Q
- Subjects
- Animals, Mice, Hydrophobic and Hydrophilic Interactions, Permeability, Rats, Staphylococcus aureus drug effects, Male, Chitosan chemistry, Chitosan pharmacology, Wound Healing drug effects, Nanofibers chemistry, Bandages, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents chemistry, Water chemistry
- Abstract
Excessive accumulation of exudate from wounds often causes infection and hinders skin regeneration. To handle wound exudate quickly and prevent infection, we developed an antibacterial Janus nanofibrous dressing with a unidirectional water-transport function. The dressing consists of a hydrophilic chitosan aerogel (CS-A) as the outer layer and a hydrophobic laurylated chitosan (La-CS) nanofibrous membrane as the inner layer. These dressings achieved excellent liquid absorption performance (2987.8 ± 123.5 %), air and moisture permeability (997.8 ± 23.1 g/m
2 /day) and mechanical strength (5.1 ± 2.6 MPa). This performance was obtained by adjusting the density of CS-A and the thickness of the La-CS membrane. Moreover, the dressing did not induce significant toxicity to cells and can prevent bacterial aggregation and infection at the wound site. Animal experiments showed that the dressing can shorten the inflammatory phase, enhance blood vessel generation, and accelerate collagen deposition, thus promoting wound healing. Overall, these results suggest that this Janus dressing is a promising material for clinical wound care., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)- Published
- 2024
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