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The growing concern about microorganism infections, especially hospital-acquired infections, has driven the demand for effective and safe agents in recent years. Herein, novel nanocomposites were prepared based on layered double hydroxides (LDH NPs), Fe 2 O 3 nanoparticles (Fe 2 O 3 NPs), and chitosan hydrogel beads in different concentrations. The characteristics and composition of the prepared materials were investigated by various techniques such as XRD, FESEM, and FTIR. The results indicate that the nanocomposites are synthesized successfully, and each component is present in hydrogel matrixes. Then, their biomedical properties, including antibacterial, antifungal, and antioxidant activity, were examined. Our findings demonstrate that the antimicrobial activity of nanocomposites significantly depends on the concentration of each component and their chemical groups. It shows itself in the result of the inhibitory zone of all bacteria or fungi samples. The obtained results indicate that the nanocomposite of Chitosan-hydrogel beads with 20% LDH and Fe 2 O 3 (CHB-LDH-Fe 2 O 3 %20) and Chitosan-hydrogel beads based on 20% LDH (CHB-LDH%20) showed excellent antibacterial and antifungal properties against all tested bacteria and fungi ( P  ≤ 0.01). In addition, the antioxidant effects of the synthesized materials (especially CHB-LDH Fe 2 O 3 %20 and CHB-LDH%20) were investigated, showing high antioxidant efficacy against DPPH free radicals ( P  ≤ 0.01). According to our findings, we can say that these materials are promising biomaterials for inhibiting some infectious bacteria and fungi., (© 2022 IOP Publishing Ltd.)

CuO nanoparticles were synthesized in situ during the formation of physically cross-linked chitosan hydrogel beads using sodium tripolyphosphate as the cross-linker. The aim of the study was to investigate whether these nanocomposite beads have the potential to be used in drug delivery applications. The formation of CuO nanoparticles (CuONPs) in the hydrogels was confirmed by X-ray diffraction and scanning electron microscopy studies. SEM micrographs revealed the formation of CuONPs with size range of 10-25 nm within the hydrogel matrix. Furthermore, the antibacterial and swelling properties of the beads were studied. The prepared nanocomposite hydrogels showed a pH sensitive swelling behavior. The CuO nanocomposite hydrogels have rather higher swelling in different aqueous solutions in comparison with neat hydrogel. The nanocomposite hydrogels demonstrated good antibacterial effects against Escherichia coli and Staphylococcus aureus bacteria., (Copyright © 2015 Elsevier B.V. All rights reserved.)

ZnO nanoparticles were synthesized in situ during the formation of physically cross-linked chitosan hydrogel beads using sodium tripolyphosphate as the cross-linker. The aim of the study was to investigate whether these nanocomposite beads have the potential to be used in drug delivery applications. The formation of ZnO nanoparticles (ZnONPs) in the hydrogels was confirmed by X-ray diffraction and scanning electron microscopy studies. SEM micrographs revealed the formation of ZnONPs with size range of 10-25 nm within the hydrogel matrix. Furthermore, the swelling and drug release properties of the beads were studied. The prepared nanocomposite hydrogels showed a pH sensitive swelling behavior. The ZnO nanocomposite hydrogels have rather higher swelling ratio in different aqueous solutions in comparison with neat hydrogel. In vitro drug release test was carried out to prove the effectiveness of this novel type of nanocomposite beads as a controlled drug delivery system. A prolonged and more controlled drug releases were observed for ZnONPs containing chitosan beads, which increased by the increase in ZnONPs content., (Copyright © 2015 Elsevier B.V. All rights reserved.)

Silver nanoparticles were synthesized in situ during the formation of physically crosslinked chitosan hydrogel beads using sodium tripolyphosphate as the crosslinker. The aim of the study was to investigate whether these nanocomposite beads have the potential to be used in drug delivery applications. The formation of silver nanoparticles (AgNPs) in the hydrogels was confirmed by X-ray diffraction and scanning electron microscopy studies. Furthermore, the antibacterial and swelling properties of the beads were studied. The nanocomposite hydrogels demonstrated good antibacterial effects against Escherichia coli and Staphylococcus aureus bacteria. AgNPs caused an increase in the swelling capacity of the beads. In vitro drug release test was carried out to prove the effectiveness of this novel type of nanocomposite beads as a controlled drug delivery system. Prolonged and more controlled drug releases were observed for AgNPs containing chitosan beads, which increased by the increase in AgNPs content., (Copyright © 2015 Elsevier B.V. All rights reserved.)

In this research, a novel dual-responsive supermagnetic chitosan/iron oxide nanocomposite hydrogel beads (CH/MION) was prepared using sodium tripolyphosphate (STPP) as cross linking agent. The prepared CH/MION hydrogel was systematically characterized by Fourier transforminfrared spectroscopy (FT-IR), scanning electron microscopy (SEM) X-ray diffraction (XRD), and vibrating sample magnetometer (VSM). In addition, the CH/MION hydrogel exhibits favorable swelling properties that are sensitive to pH, and external magnetic field (EMF). The drug release behavior of the prepared hydrogel under EMF, and different pHs was also studied. The obtained hydrogel showed considerable temperature, pH, and EMF sensitivity for the in vitro release of Doxorubicin (DOX).These results suggested that the CH/MION hydrogel beads could be a promising candidate for drug delivery applications. [ABSTRACT FROM AUTHOR]