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Periodontitis is a chronic inflammatory disease caused by bacteria, and topical medication is the most efficient way to treat it. Injectable hydrogels have been used in the treatment of periodontitis because of their injectability, excellent biocompatibility, and controlled drug-release properties. However, conventional injectable hydrogels lack self-healing properties or have weak mechanical properties, which render them unable to adapt to the intricate oral environment of periodontal tissues. Therefore, a double cross-linked network hydrogel was prepared in this study using poly(vinyl alcohol) and hydroxypropyl chitosan as substrates, and the properties of the hydrogels were evaluated by altering the concentration of poly(vinyl alcohol). Experimental evidence indicates that the hydrogels showed excellent biocompatibility, degradation performances, slow-release properties of the drug (168 h), and significant antibacterial efficacy against E. coli (86.18 %) and S. aureus (85.69 %). Additionally, the hydrogel exhibited favorable mechanical properties (18.20 KPa), self-healing capabilities, and injectability because of the synergistic interaction of multiple dynamic covalent bonds, which allowed it to adapt to the complex therapeutic conditions of the oral cavity. These excellent properties suggest that the hydrogel has the potential to be used as a drug carrier for periodontitis treatment. [Display omitted] • The hydrogel exhibited excellent injectability and self-healing properties. • The mechanical property of the hydrogel was enhanced due to the double crosslinked network. • The hydrogel showed a favorable slow-release drug performance. • Excellent biocompatibility ensures the safety of the hydrogel for in vivo applications. [ABSTRACT FROM AUTHOR]

The proportion of individuals with bladder cancer has drastically increased, thereby rendering bladder cancer a focus of social concern and great challenge for human health management. Hydrogels with three-dimensional network structures have attracted considerable attention in the field of drug delivery for tumor therapy. Therefore, exploring hydrogel drug-delivery systems with excellent biocompatibility and targeting ability is a current research hotspot. Herein, a chitosan/dialdehyde sodium alginate/magnetic dopamine hydrogel was investigated for this purpose. The hydrogel was prepared from chitosan using sodium dialdehyde alginate and dopamine via grafting, crosslinking, and compounding. Furthermore, characterization of the product structure, targeted adhesion, and evaluation of drug delivery properties were performed. The prepared wall-adherent hydrogel materials exhibited excellent targeted drug-delivery and controlled-release properties. In addition, the effect of dopamine dosage on the performance of drug-loaded hydrogels was examined. In conclusion, the drug-delivery materials exhibited strong organ-wall adhesion, hydrogel properties, targeting ability, antibacterial and antimicrobial abilities (98%), and biocompatibility (99%). Based on these excellent properties, the constructed targeted hydrogels demonstrate considerable potential for drug delivery and bladder cancer treatment. [Display omitted] • Wall-adhered, targeted hydrogel for drug delivery in bladder cancer treatment. • Preparation of hydrogels with excellent biocompatibility from chitosan and sodium dialdehyde alginate. • Long-term targeted adhesion and drug release. • Excellent antibacterial and bacteriostatic properties. [ABSTRACT FROM AUTHOR]