1. Synthesis, characterization, and antibacterial activity of cross-linked chitosan-glutaraldehyde.
- Author
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Li B, Shan CL, Zhou Q, Fang Y, Wang YL, Xu F, Han LR, Ibrahim M, Guo LB, Xie GL, and Sun GC
- Subjects
- Anti-Bacterial Agents chemical synthesis, Anti-Bacterial Agents chemistry, Chitosan chemical synthesis, Chitosan chemistry, Cross-Linking Reagents chemistry, Drug Resistance, Bacterial, Glutaral chemical synthesis, Glutaral chemistry, Hot Temperature, Microscopy, Electron, Scanning, Spectroscopy, Fourier Transform Infrared, Temperature, Thermogravimetry, Time Factors, X-Ray Diffraction, Anti-Bacterial Agents pharmacology, Burkholderia cepacia drug effects, Chitosan pharmacology, Glutaral pharmacology
- Abstract
This present study deals with synthesis, characterization and antibacterial activity of cross-linked chitosan-glutaraldehyde. Results from this study indicated that cross-linked chitosan-glutaraldehyde markedly inhibited the growth of antibiotic-resistant Burkholderia cepacia complex regardless of bacterial species and incubation time while bacterial growth was unaffected by solid chitosan. Furthermore, high temperature treated cross-linked chitosan-glutaraldehyde showed strong antibacterial activity against the selected strain 0901 although the inhibitory effects varied with different temperatures. In addition, physical-chemical and structural characterization revealed that the cross-linking of chitosan with glutaraldehyde resulted in a rougher surface morphology, a characteristic Fourier transform infrared (FTIR) band at 1559 cm⁻¹, a specific X-ray diffraction peak centered at 2θ = 15°, a lower contents of carbon, hydrogen and nitrogen, and a higher stability of glucose units compared to chitosan based on scanning electron microscopic observation, FTIR spectra, X-ray diffraction pattern, as well as elemental and thermo gravimetric analysis. Overall, this study indicated that cross-linked chitosan-glutaraldehyde is promising to be developed as a new antibacterial drug.
- Published
- 2013
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