8 results on '"Wen, Shu"'
Search Results
2. Prescription patterns and factors influencing the use of Chinese herbal medicine among pregnant women in Taiwan: a population-based retrospective study.
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Wen, Shu-Hui, Chang, Wei-Chuan, Shen, Hsuan-Shu, and Wu, Hsien-Chang
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CONFIDENCE intervals ,DATABASES ,DRUG prescribing ,HERBAL medicine ,CHINESE medicine ,PROBABILITY theory ,RESEARCH funding ,COMORBIDITY ,PHYSICIAN practice patterns ,MULTIPLE regression analysis ,SOCIOECONOMIC factors ,RETROSPECTIVE studies ,DESCRIPTIVE statistics ,ODDS ratio ,THERAPEUTICS ,PREGNANCY - Abstract
Background: The use of Chinese herbal medicine (CHM) has been widely promoted as a natural and safe way to treat illness during pregnancy. However, prescription patterns and factors influencing its use are largely unknown. Therefore, we conducted a population-based study to address these questions. Methods: Pregnant women aged 18–50 years were selected from Taiwan's National Health Insurance Research Database between 2001 to 2011. CHM prescriptions and diagnostic records were collected. Demographic data and pre-existing diseases were compared between CHM users and non-users. A multivariate logistic regression analysis was performed to identify possible factors influencing the use of CHM during pregnancy. Results: A total of 81,873 eligible prescription records were identified, and 16,553 pregnant women were prescribed CHM during pregnancy, yielding a CHM prescription rate of 20.2%. The three most frequently used herbs were Scutellariae Radix (Huang Qin) (4.4%), Eucommiae cortex (Du Zhong) (2.5%), and Atractylodes Rhizome (Bai Zhu) (2.4%). The most frequently used herbal formulae were Dang-Guei-Shao-Yao-San (4.1%), Jia-Wei-Xiao-Yao-San (3.5%), and Xiang-Sha-Liu-Jun-Zi-Tang (2.6%). Multivariate logistic regression revealed that subjects with an older age, a university education, a pre-pregnancy history of CHM use, asthma, chronic renal disease, and cardiac valvular disease and living in a residential area other than northern Taiwan had an increase in adjusted odds ratio for CHM use during pregnancy. Conclusions: In this population-based study, we found that demographic factors and pre-existing diseases were associated with the use of CHM among pregnant women. It is worth noting that Leonuri Herba (Yi Mu Cao) and Shao-Fu-Zhu-Yu-Tang should be used with caution in the first trimester. Further research is needed to explore the safety and effectiveness of the use of CHM in pregnant women. [ABSTRACT FROM AUTHOR]
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- 2020
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3. Concurrent use of Chinese herbal medicine among hormone users and its association with ischemic stroke risk: A population-based study.
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Wen, Shu-Hui, Chang, Wei-Chuan, Hong, Mun-Kun, and Wu, Hsien-Chang
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CEREBRAL ischemia , *CONFIDENCE intervals , *HERBAL medicine , *HORMONE therapy , *CHINESE medicine , *MENOPAUSE , *MULTIVARIATE analysis , *STATISTICAL sampling , *MATHEMATICAL variables , *PROPORTIONAL hazards models , *POPULATION-based case control , *DISEASE risk factors ,STROKE risk factors - Abstract
Ethnopharmacological relevance Previous studies had indicated that hormone therapy (HT) may increase the risk of ischemic stroke (IS) in menopausal women. However, little is known about the benefits and risks of use of Chinese herbal medicine (CHM) in conditions related to hormone use. The aim of this study is to explore the risk of IS in menopausal women treated with HT and CHM. Materials and methods A total of 32,441 menopausal women without surgical menopause aged 40–65 years were selected from 2003 to 2010 using the 2-million random samples of the National Health Insurance Research Database in Taiwan. According to the medication usage of HT and CHM, we divided the current and recent users into two groups: an HT use-only group (n = 4989) and an HT/CHM group (n = 9265). Propensity-score matching samples (4079 pairs) were further created to deal with confounding by indication. The adjusted hazard ratios (HR) of IS were estimated by the robust Cox proportional hazards model. Results The incidence rate of IS in the HT/CHM group was significantly lower than in the HT group (4.5 vs. 12.8 per 1000 person-year, p < 0.001). Multivariate analysis results indicated that additional CHM use had a lower risk of IS compared to the HT group (HR = 0.3; 95% confidence interval [CI], 0.21–0.43). Further subgroup analyses and sensitivity analyses had similar findings. Conclusion We found that combined use of HT and CHM was associated with a lower risk of IS. Further study is needed to examine possible mechanism underlying this association. [ABSTRACT FROM AUTHOR]
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- 2018
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4. Effect of early use of Chinese herbal products on mortality rate in patients with lung cancer.
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Shen, Hsuan-Shu and Wen, Shu-Hui
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CHINESE medicine , *CANCER patients , *CONFIDENCE intervals , *CAUSES of death , *HERBAL medicine , *LONGITUDINAL method , *LUNG tumors , *SURVIVAL analysis (Biometry) , *TUMOR classification , *TREATMENT effectiveness , *PROPORTIONAL hazards models , *RETROSPECTIVE studies - Abstract
Ethnopharmacological relevance Patients with lung cancer are frequently treated with Western medical treatments. Recently, patients have begun to use Chinese medicine to strengthen the immune system and alleviate side effects. Aim of the study We aimed to evaluate the association between mortality rate and early use of Chinese herbal products (CHPs) among patients with lung cancer. Materials and methods We conducted a retrospective cohort study based on the National Health Insurance Research Database, Taiwan Cancer Registry, and Cause of Death Data. Patients with newly diagnosed lung cancer between 2002 and 2010 were classified as either the CHP ( n = 422) or the non-CHP group ( n = 2828) based on whether they used CHP within 3 months after first diagnosis of lung cancer. A robust Cox regression model was used to examine the hazard ratio (HR) of death for propensity score (PS) matching samples. Results After PS matching, average survival time of the CHP group was significantly longer than that of the non-CHP group. The adjusted HR (0.82; 95% CI: 0.73–0.92) in the CHP group was lower than the non-CHP group. Stratified by clinical cancer stages, CHP group had longer survival time in stage 3 subgroup. When the exposure period of CHP use was changed from 3 to 6 months, results remained similar (HR = 0.85; 95% CI: 0.76–0.95). Conclusion Results indicated that patients with lung cancer who used CHP within 3 months after first diagnosis had a lower hazard of death than non-CHP users, especially for stage 3 lung cancer. Further experimental studies are needed to examine the causal relationship. [ABSTRACT FROM AUTHOR]
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- 2018
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5. Evaluating Two Dioscin-Based Silica Stationary Phases and their Application to Achiral and Chiral Separations.
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Xiaojuan Gu, Kongchun Sun, Yaqiong Han, Bingquan Chang, Wen Shu, Liangyu Chen, Canyu Yang, and Baochun Shen
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HIGH performance liquid chromatography ,AMINO acid separation ,CHINESE medicine ,SILICA ,HISTIDINE - Abstract
In a previous study, polyphyllin III, an important natural dioscin ingredient, was bonded to silica particles using the "one-pot method" for preparing a stationary phase, called SP-D. SP-D was further modified to produce two stationary phases, namely the phenyl isocyanate-dioscin (Phe-D) and 3,5-dimethyl phenyl isocyanate-dioscin bonded silica stationary phase (DMP-D), respectively. The Phe-D and DMP-D were evaluated by achiral and chiral analytes. The high performance liquid chromatography (HPLC) method was optimized and applied to the analysis of the main active ingredient, polyphyllins, that were contained in gongxuening capsules, a traditional Chinese medicine (TCM) widely used to treat gynecological diseases. The two synthesized stationary phases were also applied to the separation of the amino acid (AA) enantiomers. For this study, 10 a-AAs (lysine, leucine, cysteine, arginine, isoleucine, threonine, serine, valine, alanine, and histidine) were selected and studied for chiral separation using Phe-D and DMP-D stationary phases. In this study, 10 observed AA enantiomers were separated to different degrees on at least one stationary phase whereas four AAs were enantioseparated on both Phe-D and DMP-D. These results indicated that the two synthesized stationary phases have potential applicability in quality control (QC) of TCM and chiral separation as well as offering a new application choice for analyses of natural products. [ABSTRACT FROM AUTHOR]
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- 2021
6. Antrodia cinnamomea Extract Inhibits Th17 Cell Differentiation and Ameliorates Imiquimod-Induced Psoriasiform Skin Inflammation.
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Li, Ming-Han, Wu, Hsin-Chieh, Yao, Hsin-Jan, Lin, Chi-Chen, Wen, Shu-Fang, and Pan, I-Horng
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INFLAMMATION prevention ,ANALYSIS of variance ,ANIMAL experimentation ,IMMUNOMODULATORS ,CHALONES ,CYTOKINES ,FLOW cytometry ,HERBAL medicine ,IMMUNOHISTOCHEMISTRY ,INTERLEUKINS ,MEDICINAL plants ,BOTANIC medicine ,CHINESE medicine ,MICE ,MUSHROOMS ,POLYMERASE chain reaction ,PROBABILITY theory ,PSORIASIS ,RESEARCH funding ,RNA ,STATISTICS ,T cells ,T-test (Statistics) ,TUMOR necrosis factors ,WESTERN immunoblotting ,FUNCTIONAL foods ,PLANT extracts ,DATA analysis ,TREATMENT effectiveness ,DATA analysis software - Abstract
Antrodia cinnamomea ( A. cinnamomea) is a Chinese medicinal herb that possesses a broad range of bioactivities, including anti-inflammation. Given that the proinflammatory cytokine IL-17 plays a critical role in the pathogenesis of autoimmune diseases, we investigated whether A. cinnamomea could inhibit the development of Th17 cells, the main producer of IL-17, and exhibit therapeutic effects on an animal model of psoriasis. We found that A. cinnamomea extract (AC) inhibited the differentiation of Th17 cells as well as the production of IL-17A, IL-21, and IL-22 from these cells. This effect was associated with the inhibition of STAT3 phosphorylation and RORt expression. Notably, the oral administration of AC reduced psoriasis-like inflammation in imiquimod-mediated dermal damage, repressed the expression of IL-17A, IL-22, and TNF- in skin lesions, and decreased the infiltration of CD4 T cells, CD8 T cells, and neutrophils into the dermis. Finally, serum levels of IL-17A were decreased in AC-treated mice with psoriasis-like skin inflammation. Taken together, these findings indicate that AC inhibits Th17 cell differentiation, suggesting a role for A. cinnamomea in the treatment of psoriasis and other Th17 cell-mediated inflammatory diseases. [ABSTRACT FROM AUTHOR]
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- 2015
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7. Lignans from the Flower Buds of Magnolia liliflora Desr.
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Wen-Shu Wang, Xiao-Cong Lan, Hai-Bo Wu, Yao-Zhao Zhong, Jing Li, Ying Liu, and Cong-Cong Shao
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ANALYSIS of variance , *ANIMAL experimentation , *DNA , *FLOWERS , *LIGNANS , *CHINESE medicine , *MICE , *MOLECULAR structure , *NUCLEAR magnetic resonance spectroscopy , *PHARMACEUTICAL chemistry , *TOXICITY testing , *DATA analysis software , *DESCRIPTIVE statistics - Abstract
Six new lignans, 1-6, along with six known compounds were obtained from the flower buds of Magnolia liliflora Desr. The new lignans were elucidated as (1S*,2R*,5S*,6S*)-2-(3,5-dimethoxyphenyl)-6-(3,4-methylenedioxyphenyl)-3,7-dioxabicyclo[ 3.3.0]octane (1), (1R*,2R*,5R*,6S*)-2-(3,5-dimethoxyphenyl)-6-(3,4-methylenedioxyphenyl)- 3,7-dioxabicyclo[3.3.0]octane (2), (1R*,2R*, 5R*,6S*)-2,6-bis (3,5-dimethoxyphenyl)-3,7-dioxabicyclo[ 3.3.0]octane (3), (1R*,2S*,5R*,6R*)-2-(3,4-methylenedioxyphenyl)-6-(3,5-dimethoxyphenyl)- 3,7-dioxabicyclo[3.3.0]octane (4), (7'S*, 8R*,8'R*)-3,5'-dimethoxy-3',4,9'-trihydroxy-7',9- epoxy-8,8'-lignan (5), and (7'R*,8'S*)-3,3',4,5'-tetramethoxy- 7-en-7',9-epoxy-8,8'-lignan (6), by the analysis of 1D and 2D-NMR as well as HRE-SIMS data. The capacity of compound 1 to protect against damages to the DNA of rat lymphocyte cells induced by UV irradiation was assessed by the comet assay. It showed stronger antigenotoxicity than ascorbic acid from 6 × 10-3 mmol·L-1 to 6 × 10-6 mmol·L-1. [ABSTRACT FROM AUTHOR]
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- 2012
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8. Yunpi Heluo decoction attenuates insulin resistance by regulating SIRT1-FoxO1 autophagy pathway in skeletal muscle of Zucker diabetic fatty rats.
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Mao, Zhu-Jun, Xia, Wen-Shu, and Chai, Fang
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AUTOPHAGY , *ANIMAL experimentation , *CELLULAR signal transduction , *DIABETES , *ELECTRON microscopy , *GENE expression , *HERBAL medicine , *HIGH density lipoproteins , *INSULIN resistance , *LOW density lipoproteins , *CHINESE medicine , *POLYMERASE chain reaction , *RATS , *STAINS & staining (Microscopy) , *TRANSGENIC animals , *TRIGLYCERIDES , *REVERSE transcriptase polymerase chain reaction , *SKELETAL muscle - Abstract
Diabetes is a serious chronic metabolic disorder, and type 2 diabetes mellitus (T2DM) accounts for more than 90% of all diabetes cases. Insulin resistance (IR) is an early symptom, typical feature and main pathogenesis of T2DM due to the combined effects of genetic and environmental factors. Current evidence shows that IR is mainly caused by nutrient overload, systemic fatty acid excess, fatty tissue inflammation, endoplasmic reticulum stress, oxidative stress and abnormal autophagy. Autophagy plays an important role in the development of IR and decreased autophagy activity can cause IR through various ways. Yunpiheluo (YPHL) decoction is a Chinese herbal formula with unique advantages for the treatment of T2DM. The aim of the present study was to investigate the regulatory mechanism of YPHL on the autophagy pathway in the skeletal muscle of IR Zucker diabetic fatty (ZDF) rats. T2DM ZDF rats were treated with YPHL or transfected with SIRT1 adeno-associated virus. Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), insulin resistance index (IRI) and skeletal muscle TG levels were detected in a T2DM ZDF rat model. The skeletal muscle morphology was observed by histological analysis and Oil Red O Staining. Autophagosomes were observed by transmission electron microscopy (TEM). The skeletal muscle morphology and fat deposition were observed by histological examination and Oil Red O Staining. A rat skeletal muscle IR cell model was established and transfected with SIRT1 overexpression plasmids. Cell apoptosis was observed by DAPI staining. SIRT1 levels in skeletal muscle tissues and cells were detected by qRT-PCR. The protein expressions of SIRT1, FOXo1, LC3B and P62 were detected by Western blotting. Large numbers of lipid droplets and swollen mitochondria were observed in the skeletal muscle in both model group and negative control (NC) group receiving blank plasmid. Autophagosomes were seen in the skeletal muscle of YPHL and SIRT1 groups, with no significant structural abnormality. In addition, the protein expression of LC3B was decreased and the protein expression of p62 was increased significantly in the model group as compared with the NC group. After intervention with YPHL and SIRT1 overexpression, the protein expression of LC3B was significantly increased and p62 was significantly decreased. However, there was no significant difference in cell apoptosis between the two groups. The SIRT1-FoxO1 autophagy pathway may play a significant role in the pathogenesis of IR. YPHL could increase the autophagy level by regulating the SIRT1-FoxO1 signaling pathway in the skeletal muscle and improving the lipid metabolism, thereby attenuating IR. Image 1 • Autophagy plays an important role in the development of IR. • Yunpi Heluo (YPHL) decoction is a typical example of common herbs that are used for the treatment of diabetes. • YPHL can increase the autophagy level by regulating the SIRT1-FoxO1 signaling pathway in the skeletal muscle. [ABSTRACT FROM AUTHOR]
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- 2021
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