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Copyright of Pediatru.ro is the property of MEDICHUB MEDIA, S.R.L. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Pediatru.ro is the property of MEDICHUB MEDIA, S.R.L. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Headaches are relatively common in childhood. Undue irritability in young children may be an indication of recurrent or persistent headaches. Older children may have headaches which are related to increased intracranial pressure from any cause, migraine, tension, trauma, and systemic disease. These painful episodes may precede, follow or be the only manifestation of convulsions. [ABSTRACT FROM AUTHOR]

Peroxisomes are indispensable for the synthesis of bile acids, cholesterol and lipids, including plasmalogens and other phospholipids that are present in highest concentrations in the brain, heart and muscle. Impairments of these biosynthetic pathways result in progressive multisystem disease. Peroxisomes are also critical for the oxidation of very-long-chain fatty acids and related substances, such as phytanic acid. In addition, peroxisomes accommodate many oxygen-dependent reactions and peroxisomal catalase protects against H2O2. Peroxisomal disorders can be subclassified as follows: A. Disorders of peroxisom biogenesis and peroxisomal  -oxidation (elevations of very-long-chain faty acids) B. Single peroxisomal disorders with variant phenotypes. C. Defects of plasmalogen synthesis However, this widely used classification is not optimal for a clinical and diagnostic approach to peroxisomal disorders. Symptoms and disease courses in patients with generalized versus specific peroxisomal disorders are often indistinguishable and they may vary tremendously within the same group. Further on the authors present a modified grouping of peroxisomal disorders on the basis of the simple, comprehensive diagnostic approach outlined below. Clinical presentations, routine laboratory investigations and specialized investigations of peroxisomal disorders are discussed in the end. [ABSTRACT FROM AUTHOR]

Thrombosis is a rare situation in pediatric practice. That makes it impossible to have homogenous series and therefore treatment regimens are difficult to be well defined. In this article the authors present: - neonatal thrombosis (arterial and venous), thrombosis in infants and older children; - treatment regimens (indications regarding the etiology) in neonates, infants, children; - thrombolitic treatment (dosage, duration of treatment, precautions and biologic follow-up); - conclusions. [ABSTRACT FROM AUTHOR]