9 results on '"Pan, Zhengxia"'
Search Results
2. Clinical presentation and treatment of four children with pulmonary mucoepidermoid carcinoma.
- Author
-
Yang, Yiting, Wang, Quan, Pan, Zhengxia, Li, Hongbo, An, Yong, and Wu, Chun
- Subjects
MUCOEPIDERMOID carcinoma ,SYMPTOMS ,CANCER relapse ,CHILDREN'S hospitals ,PHYSICIANS - Abstract
Primary lung cancer in childhood is extremely rare, with an incidence rate of less than 2/100,0000, and pulmonary mucoepidermoid carcinoma (PMEC), is even rarer. Their symptoms are usually not specific, and there are no guidelines for their management, which makes their clinical management a challenge for pediatricians. The purpose of this report is to discuss the clinical presentation, positive signs, examinations, pathological characteristics, surgical modalities, chemotherapy regimens, and prognosis in children. The clinical data of four patients diagnosed with PMEC at the Children's Hospital of Chongqing Medical University from June 2021 to November 2022 were retrospectively analyzed, and their clinical features, treatment, and prognosis were summarized. Among them, two were male and two were female; their ages ranged from 3 years and 10 months to 10 years and 11 months, and all were staged according to tumor node metastasis classification (TNM). Immunohistochemical tests were performed in all children, among which four cases were positive for cytokeratin (CK), two cases were positive for CK7, four cases were positive for p63, about 5โ10% of tumor cells were positive for Ki67. Among the four children, three had surgery alone and one had surgery + chemotherapy. All four children are presently living, with no evidence of tumor recurrence or metastasis. PMEC in children is very rare, and its age of onset and symptoms are not specific, and there is no obvious correlation with gender. Its diagnosis mainly relies on pathomorphological diagnosis, and immunohistochemical detection has no specific performance. The prognosis of children with PMEC is related to the clinical stage and whether surgery is performed. Whether further chemotherapy or radiotherapy is needed for patients who cannot undergo surgical resection and for those who have a combination of distant metastases requires further clinical studies. Plain Language Summary: Clinical presentation and treatment of 4 children with pulmonary mucoepidermoid carcinoma Lung cancer in childhood is extremely rare, occurring at a rate of less than 2/1000000, and a type of lung cancer called pulmonary mucoepidermoid carcinoma (PMEC), is even rarer. The symptoms are usually not specific, and there are no guidelines for its management, which is a challenge for doctors. The purpose of this report is to discuss the signs and symptoms medical examinations, disease characteristics, surgical procedures, chemotherapy regimens and prognosis in children with pulmonary mucoepidermoid carcinoma. The clinical data of four patients diagnosed with pulmonary mucoepidermoid carcinoma at the Children's Hospital of Chongqing Medical University from June 2021 to November 2022 were analyzed, and their clinical features, treatment and prognosis were summarized. All four children are currently alive, and there is no recurrence or spread of the tumor after treatment. We have discussed various aspects of the disease, such as the rate of occurrence, causes, signs and symptoms, the way in which it might be diagnosed and treated, and the survival rate after operation, hoping to provide some insights for future work. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
3. Experience of diagnosis and treatment of traumatic bronchial rupture in children in a single clinical center
- Author
-
Li, Yonggang, Wang, Gang, Wu, Chun, Pan, Zhengxia, Li, Hongbo, Wang, Quan, Wang, Yi, and Dai, Jiangtao
- Published
- 2020
- Full Text
- View/download PDF
4. Video-assisted thoracoscopic surgery for non-cystic fibrosis bronchiectasis in children.
- Author
-
Ding, Fengxia, Pan, Zhengxia, Wu, Chun, Li, Hongbo, Li, Yonggang, An, Yong, Dai, Jiangtao, Wang, Gang, and Liu, Bo
- Subjects
BRONCHIECTASIS ,VIDEO-assisted thoracic surgery ,THORACOTOMY ,ARTIFICIAL respiration ,SURGICAL blood loss ,PEDIATRIC respiratory diseases ,CHEST endoscopic surgery ,CHILDREN'S hospitals - Abstract
Background: Pediatric bronchiectasis is a common respiratory disease in children. The use of video-assisted thoracoscopic surgery (VATS) for its treatment remains controversial. Objectives: The objective of our study was to compare and analyze the clinical efficacy of thoracoscopic surgery and thoracotomy in the treatment of pediatric bronchiectasis and summarize the surgical treatment experience of VATS in children with bronchiectasis. Design: Retrospective single-center cohort study. Methods: A retrospective analysis was conducted on the clinical data of 46 pediatric patients who underwent surgery with bronchiectasis at the Children's Hospital of Chongqing Medical University from May 2015 to May 2023. The patients were divided into two groups: the VATS group (25 cases) and the thoracotomy group (21 cases). Comparative analysis was performed on various parameters including basic clinical data, surgical methods, operation time, intraoperative blood loss, transfusion status, postoperative pain, postoperative mechanical ventilation time, chest tube drainage time, length of hospital stay, incidence of complications, and follow-up information. Results: There were no statistically significant differences between the two groups of patients in terms of age, weight, gender, etiology, duration of symptoms, site of onset, and comorbidities (p > 0.05). The operation time in the VATS group was longer than that in the thoracotomy group (p < 0.001). However, the VATS group had better outcomes in terms of intraoperative blood loss, transfusion status, postoperative pain, postoperative mechanical ventilation time, chest tube drainage time, and length of hospital stay (p < 0.05). The incidence of postoperative complications in the VATS group was lower than that in the thoracotomy group, although the difference was not statistically significant (p = 0.152). Follow-up data showed no statistically significant difference in the surgical treatment outcomes between the two groups (p = 0.493). Conclusion: The incidence of complications and mortality in surgical treatment of bronchiectasis is acceptable. Compared with thoracotomy surgery, VATS has advantages such as smaller trauma, less pain, faster recovery, and fewer complications. For suitable pediatric patients with bronchiectasis, VATS is a safe and effective surgical method. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
5. Simultaneous repair of congenital heart defects and pectus excavatum in young children
- Author
-
Wang, Junke, Wang, Quan, and Pan, Zhengxia
- Published
- 2018
- Full Text
- View/download PDF
6. Torsed extralobar pulmonary sequestration associated with congenital lobar emphysema: a rare entity.
- Author
-
Wu, Yuhao, Xi, Linyun, Pan, Zhengxia, Wu, Chun, and Li, Hongbo
- Subjects
MEDIASTINAL tumors ,THORACIC aorta ,CHEST endoscopic surgery ,COMPUTED tomography ,ABDOMINAL pain ,CHEST pain ,TORSION abnormality (Anatomy) - Abstract
Pulmonary sequestration (PS) is a rare congenital malformation, which mainly contains two variants involving extralobar and intralobar sequestrations. Extralobar sequestrations (ELS) are isolated from the remaining lung tissue and have their visceral pleura. Herein, we report the first case of a torsed ELS associated with congenital lobar emphysema. We described a boy who mainly presented with abdominal and chest pain. A contrast-enhanced computed tomography (CT) scan revealed a mildly enhanced posterior mediastinal mass with left lower lobar emphysema. Thoracoscopic surgery identified a dark and hemorrhagic mass that was connected to the thoracic aorta by a twisted feeding vessel and had its visceral pleura. Pathological findings were consistent with an ELS that had undergone torsion and infarction. The postoperative recovery was uneventful. For the left lower lobar emphysema, he was required for a regular outpatient follow-up. In conclusion, although extremely rare, physicians should maintain a high index of suspicion for torsed ELS when a posterior mediastinal mass with abdominal or chest pain is presented in children. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
7. A Giant Dendritic Fibromyxolipoma in the Right Thorax: A Rare Entity.
- Author
-
Li, Hongbo, Zhu, Jin, Shen, Lianju, Pan, Zhengxia, Wu, Chun, and Wu, Yuhao
- Subjects
COMPUTED tomography ,IMMUNOSTAINING ,BLOOD vessels ,CD34 antigen ,FAT cells ,BENIGN tumors - Abstract
Dendritic fibromyxolipoma (DFML) is an uncommon benign tumor. We report the first DFML in the right thorax of a child. An 11-year-old girl was admitted because of a giant tumor in the right thorax. An enhanced chest CT scan indicated a thoracic mass with mild enhancement. Thoracoscopic biopsy revealed that the tumor was composed of stellate and spindle cells embedded within abundant myxoid stroma. Additionally, mature adipocytes, cytoplasmic dendritic processes, short strands of keloidal-type collagen, and plexiform blood vessels were observed. Immunohistochemical staining indicated positive for CD34 and BCL-2. DDIT3 alteration or MDM2 amplification were not observed. The diagnosis of DFML was considered, and complete tumorectomy was performed. In conclusion, definite diagnosis of DFML should be made according to the pathologic features. Accurate diagnosis is crucial to avoid overtreatment because DFML potentially can be mistaken for more aggressive neoplasms. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
8. Application of Three-Dimensional Pseudocontinuous Arterial Spin Labeling Perfusion Imaging in the Brains of Children With Autism.
- Author
-
Tang, Shilong, Liu, Xianfan, Ran, Qiying, Nie, Lisha, Wu, Lan, Pan, Zhengxia, and He, Ling
- Subjects
AUTISTIC children ,AUTISM in children ,PERFUSION imaging ,SPIN labels ,BRAIN imaging - Abstract
Objective: To explore the application of three-dimensional pseudocontinuous arterial spin labeling (3D-PCASL) perfusion imaging in the brains of children with autism and to understand the characteristics of cerebral blood perfusion in children with autism. Methods: A total of 320 children with autism (160 men and 160 women) aged between 2 and 18 years and 320 age- and sex-matched healthy children participated in the study. All children were scanned by 3.0 T magnetic resonance axial T1 fluid-attenuated inversion recovery (FLAIR), T2 FLAIR, 3D-T1, and 3D-PCASL sequences. After postprocessing, cerebral blood flow (CBF) values in each brain region of children with autism and healthy children at the same age were compared and analyzed. Furthermore, CBF characteristics in each brain region of autistic children at various ages were determined. Results: The CBF values of the frontal lobe, hippocampus, temporal lobe, and caudate nucleus of children with autism are lower than those of healthy children (P < 0.05). Additionally, as the ages of children with autism increase, the number of brain regions with decreased CBF values gradually increases. A receiver operating characteristic (ROC) analysis results show that the CBF values of the frontal lobe, hippocampus, temporal lobe, and caudate nucleus can distinguish children with autism [area under the ROC curve (AUC) > 0.05, P < 0.05]. Conclusion: The 3D-PCASL shows lower brain CBF values in children with autism. Clinical Trial Registration: www.ClinicalTrials.gov, identifier: ChiCTR2000034356. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
9. Congenital diaphragmatic eventration in children: 12 years' experience with 177 cases in a single institution.
- Author
-
Wu, Shengde, Zang, Na, Zhu, Jin, Pan, Zhengxia, and Wu, Chun
- Abstract
Objective This study sought to summarize the diagnostic and treatment aspects of congenital diaphragmatic eventration (CDE) in children by retrospectively analyzing their medical records to identify and understand the complications of CDE, its treatment, and to evaluate the long-term outcomes of diaphragmatic plication. Methods The medical records of children who received treatment for CDE from January 2000 to December 2011 at the Children's Hospital of Chongqing Medical University, China were analyzed. Data analyzed included the following: age, sex, symptom, location of eventration, associated anomalies, surgical procedures, complications, and survival and follow up details after diaphragmatic plication. Results The medical records of 177 children (boys: 128, girls: 49, mean age: 10.28 ± 2.35 months) with CDE were included in this study. Specific symptoms of eventration of the diaphragm were reported for 86 cases; and the typical symptoms included rapid breathing, vomiting, and recurrent respiratory infections. Except for a bilateral case, all the other patients had unilateral CDE. Associated malformations were observed in 31 cases (17.5%), hypoplastic lung (10 cases) was the most common followed by congenital heart disease (9 cases), and cryptorchidism (3 cases). Interestingly, 91 patients were asymptomatic. Diaphragmatic plication was performed in all symptomatic patients (86 cases, 48.5%) and none had recurrence. Conclusions Clinical symptoms of CDE varied in severity, ranging from asymptomatic conditions to life-threatening respiratory distress. Timely accurate diagnosis and treatment of symptomatic CDE could effectively resolve respiratory morbidity and reduce complications. The diaphragm plication surgery provided good results among the study population with no recurrence. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.